Optimization of synthetic route to PNA-T-OH monomers

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2018-01-01

Author

ALPTÜRK, ONUR
YEŞILBAŞ, SEVCAN
SARIOĞLU, GÖZDE
KARAÇAYLI, ASLI
SAYLAM, AYTÜL
Özçubukçu, Salih

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Peptide nucleic acids are synthetic molecules crafted to mimic natural nucleic acids, and thus, they are widely utilized in many chemical, and, biomedical applications. Although there exist many approaches to synthesize monomers to date, there is still room to improve these methodologies. With this motivation, we compared some widely utilized synthetic routes to obtain N-Boc-PNA-T-OH, and N-Fmoc-PNA-T-OH. Our results indicate that N-Bocethylenediamine is the most pivotal intermediate in the chemistry of PNA, and synthetic route commencing with this material affords these two PNA monomers in relatively high yield, and purity, while being very reproducible.

Subject Keywords

Peptide nucleic acid, Monomer synthesis, Optimization

URI

https://hdl.handle.net/11511/37812

Journal

Journal of the Turkish Chemical Society, Section A: Chemistry

DOI

https://doi.org/10.18596/jotcsa.380410

Collections

Department of Chemistry, Article

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Citation Formats

O. ALPTÜRK, S. YEŞILBAŞ, G. SARIOĞLU, A. KARAÇAYLI, A. SAYLAM, and S. Özçubukçu, “Optimization of synthetic route to PNA-T-OH monomers,” Journal of the Turkish Chemical Society, Section A: Chemistry, pp. 457–468, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37812.