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FGX: a frequentist gene expression index for Affymetrix arrays
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Date
2007-04-01
Author
Purutçuoğlu Gazi, Vilda
Wit, Ernst
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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We consider a new frequentist gene expression index for Affymetrix oligonucleotide DNA arrays, using a similar probe intensity model as suggested by Hein and others (2005), called the Bayesian gene expression index (BGX). According to this model, the perfect match and mismatch values are assumed to be correlated as a result of sharing a common gene expression signal. Rather than a Bayesian approach, we develop a maximum likelihood algorithm for estimating the underlying common signal. In this way, estimation is explicit and much faster than the BGX implementation. The observed Fisher information matrix, rather than a posterior credibility interval, gives an idea of the accuracy of the estimators. We evaluate our method using benchmark spike-in data sets from Affymetrix and GeneLogic by analyzing the relationship between estimated signal and concentration, i.e. true signal, and compare our results with other commonly used methods.
Subject Keywords
Statistics, Probability and Uncertainty
,
Statistics and Probability
,
General Medicine
URI
https://hdl.handle.net/11511/38608
Journal
BIOSTATISTICS
DOI
https://doi.org/10.1093/biostatistics/kxl020
Collections
Department of Statistics, Article