RNA-biology ruling cancer progression? Focus on 3 ' UTRs and splicing

Date

2020-09-01

Author

Erson Bensan, Ayşe Elif

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

58
views

0
downloads

The protein-coding regions of mRNAs have the information to make proteins and hence have been at the center of attention for understanding altered protein functions in disease states, including cancer. Indeed, the discovery of genomic alterations and driver mutations that change protein levels and/or activity has been pivotal in our understanding of cancer biology. However, to better understand complex molecular mechanisms that are deregulated in cancers, we also need to look at non-coding parts of mRNAs, including 3 ' UTRs (untranslated regions), which control mRNA stability, localization, and translation efficiency. Recently, these rather overlooked regions of mRNAs are gaining attention as mounting evidence provides functional links between 3 ' UTRs, protein functions, and cancer-related molecular mechanisms. Here, roles of 3 ' UTRs in cancer biology and mechanisms that result in cancer-specific 3 '-end isoform variants will be reviewed. An increased appreciation of 3 ' UTRs may help the discovery of new ways to explain as of yet unknown oncogene activation and tumor suppressor inactivation cases in cancers, and provide new avenues for diagnostic and therapeutic applications.

Subject Keywords

Cancer research, Oncology, mRNA, UTR, Splicing, Polyadenylation, microRNA, RNA-binding protein, Mutation, Structural variation, TP53, MYC, PD-L1, BRAF

URI

https://hdl.handle.net/11511/38697

Journal

CANCER AND METASTASIS REVIEWS

DOI

https://doi.org/10.1007/s10555-020-09884-9

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Differential activation of immune cells by commensal versus pathogen-derived bacterial DNA Günalp, Sinem; Gürsel, Mayda; Department of Biology (2015) Immunological mechanisms making contribution to discriminating signals obtained from commensal versus pathogenic bacteria is an active area of research and recent evidence proposes that commensals and pathogens might express discrete variants of pathogen associated molecular patterns (PAMP). We hypothesized that as a major member of PAMP, bacterial DNA (bacDNA) originating from commensals versus pathogens might possess distinct immunostimulatory activities, enabling their dis- crimination by the immune syst...
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system Erson Bensan, Ayşe Elif (2008-10-01) Since the discovery of microRNAs (miRNAs) in Caenorhabditis elegans, mounting evidence illustrates the important regulatory roles for miRNAs in various developmental, differentiation, cell proliferation, and apoptosis pathways of diverse organisms. We are just beginning to elucidate novel aspects of RNA mediated gene regulation and to understand how heavily various molecular pathways rely on miRNAs for their normal function. miRNAs are small non-protein-coding transcripts that regulate gene expression post-...
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. KHURANA, V; et. al. (2017-02-22) Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (alpha-syn), a protein central to Parkinson's disease. Genome-wide screens in yeast identified 332 genes that impact alpha-syn toxicity. To "humanize'' this molecular network, we developed a computational method, Transpose Net. This integrates a Steiner prize-collecting approach w...
PCR cloning and heterologous expression of Scytalidium thermophilum laccase gene in Aspergillus sojae Koçlar, Gülden; Ögel, Zümrüt Begüm; Department of Biotechnology (2005) In this study, Scytalidium thermophilum laccase gene was first cloned into E. coli and then heterologously expressed in A. sojae. S. thermophilum is a thermophilic fungus with an important role in determining selectivity of compost produced for growing Agaricus bisporus. S. thermophilum laccase gene was first cloned by Novo Nordisk Bio Tech, Inc. in 1998. This laccase gene (lccS) has an open reading frame of 2092bp. It is composed of five exons punctuated by four small introns. The coding region, excluding ...
Functional characterization of microrna-125b expression in MCF7 breast cancer cell line Tuna, Serkan; Erson Bensan, Ayşe Elif; Department of Biology (2010) microRNA dependent gene expression regulation has roles in diverse processes such as differentiation, proliferation and apoptosis. Therefore, deregulated miRNA expression has functional importance for various diseases, including cancer. miR-125b is among the commonly downregulated miRNAs in breast cancer cells . Therefore we aimed to characterize the effects of miR-125b expression in MCF7 breast cancer cell line (BCCL) to better understand its roles in tumorigenesis. Here, we investigated mir-125 family mem...

Citation Formats

A. E. Erson Bensan, “RNA-biology ruling cancer progression? Focus on 3 ′ UTRs and splicing,” CANCER AND METASTASIS REVIEWS, pp. 887–901, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38697.