RNA-biology ruling cancer progression? Focus on 3 ' UTRs and splicing

Date

2020-09-01

Author

Erson Bensan, Ayşe Elif

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

213
views

0
downloads

The protein-coding regions of mRNAs have the information to make proteins and hence have been at the center of attention for understanding altered protein functions in disease states, including cancer. Indeed, the discovery of genomic alterations and driver mutations that change protein levels and/or activity has been pivotal in our understanding of cancer biology. However, to better understand complex molecular mechanisms that are deregulated in cancers, we also need to look at non-coding parts of mRNAs, including 3 ' UTRs (untranslated regions), which control mRNA stability, localization, and translation efficiency. Recently, these rather overlooked regions of mRNAs are gaining attention as mounting evidence provides functional links between 3 ' UTRs, protein functions, and cancer-related molecular mechanisms. Here, roles of 3 ' UTRs in cancer biology and mechanisms that result in cancer-specific 3 '-end isoform variants will be reviewed. An increased appreciation of 3 ' UTRs may help the discovery of new ways to explain as of yet unknown oncogene activation and tumor suppressor inactivation cases in cancers, and provide new avenues for diagnostic and therapeutic applications.

Subject Keywords

Cancer research, Oncology, mRNA, UTR, Splicing, Polyadenylation, microRNA, RNA-binding protein, Mutation, Structural variation, TP53, MYC, PD-L1, BRAF

URI

https://hdl.handle.net/11511/38697

Journal

CANCER AND METASTASIS REVIEWS

DOI

https://doi.org/10.1007/s10555-020-09884-9

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Differential activation of immune cells by commensal versus pathogen-derived bacterial DNA Günalp, Sinem; Gürsel, Mayda; Department of Biology (2015) Immunological mechanisms making contribution to discriminating signals obtained from commensal versus pathogenic bacteria is an active area of research and recent evidence proposes that commensals and pathogens might express discrete variants of pathogen associated molecular patterns (PAMP). We hypothesized that as a major member of PAMP, bacterial DNA (bacDNA) originating from commensals versus pathogens might possess distinct immunostimulatory activities, enabling their dis- crimination by the immune syst...
PCR cloning and heterologous expression of Scytalidium thermophilum laccase gene in Aspergillus sojae Koçlar, Gülden; Ögel, Zümrüt Begüm; Department of Biotechnology (2005) In this study, Scytalidium thermophilum laccase gene was first cloned into E. coli and then heterologously expressed in A. sojae. S. thermophilum is a thermophilic fungus with an important role in determining selectivity of compost produced for growing Agaricus bisporus. S. thermophilum laccase gene was first cloned by Novo Nordisk Bio Tech, Inc. in 1998. This laccase gene (lccS) has an open reading frame of 2092bp. It is composed of five exons punctuated by four small introns. The coding region, excluding ...
Functional characterization of microrna-125b expression in MCF7 breast cancer cell line Tuna, Serkan; Erson Bensan, Ayşe Elif; Department of Biology (2010) microRNA dependent gene expression regulation has roles in diverse processes such as differentiation, proliferation and apoptosis. Therefore, deregulated miRNA expression has functional importance for various diseases, including cancer. miR-125b is among the commonly downregulated miRNAs in breast cancer cells . Therefore we aimed to characterize the effects of miR-125b expression in MCF7 breast cancer cell line (BCCL) to better understand its roles in tumorigenesis. Here, we investigated mir-125 family mem...
Novel BRCA2 pathogenic genotype and breast cancer phenotype discordance in monozygotic triplets Duzkale, Neslihan; EYERCİ, NİLNUR; Oksuzoglu, Berna; Teker, Taner; Kandemir, Olcay (Elsevier BV, 2020-04-01) BRCA1/2 genes with high-penetrance are tumor suppressor and tumor susceptibility genes that play important roles in the homologous recombination mechanism in DNA repair and increase breast cancer risk. Variants in BRCA1 or BRCA2 are the main causes of familial and early-onset breast cancer. This study investigated pathogenic variant belonging to the BRCA2 gene splice region in monozygotic triplets. A 44-year-old woman was diagnosed with breast cancer when she was 32 years old. Her monozygotic sister had a h...
Chromosome segregation in Escherichia coli division: A free energy-driven string model Fan, J.; Tuncay, Kağan; Ortoleva, P. J. (Elsevier BV, 2007-08-01) Although the mechanisms of eukaryotic chromosome segregation and cell division have been elucidated to a certain extent, those for bacteria remain largely unknown. Here we present a computational string model for simulating the dynamics of Escherichia coli chromosome segregation. A novel thermal-average force field accounting for stretching, bending, volume exclusion, friction and random fluctuation is introduced. A Langevin equation is used to simulate the chromosome structural changes. The mechanism of ch...

Citation Formats

A. E. Erson Bensan, “RNA-biology ruling cancer progression? Focus on 3 ′ UTRs and splicing,” CANCER AND METASTASIS REVIEWS, pp. 887–901, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38697.