Voxel-MARS: a method for early detection of Alzheimer's disease by classification of structural brain MRI

Cevik, Alper
Weber, Gerhard-Wilhelm
Eyüboğlu, Behçet Murat
Oguz, Kader Karli
Neuroscience is of emerging importance along with the contributions of Operational Research to the practices of diagnosing neurodegenerative diseases with computer-aided systems based on brain image analysis. Although multiple biomarkers derived from Magnetic Resonance Imaging (MRI) data have proven to be effective in diagnosing Alzheimer's disease (AD) and mild cognitive impairment (MCI), no specific system has yet been a part of routine clinical practice. This paper aims to introduce a fully-automated voxel-based procedure, Voxel-MARS, for detection of AD and MCI in early stages of progression. Performance was evaluated on a dataset of 508 MRI volumes gathered from the Alzheimer's Disease Neuroimaging Initiative database. Data were transformed into a high-dimensional space through a feature extraction process. A novel 3-step feature selection procedure was applied. Multivariate Adaptive Regression Splines method was used as a classifier for the first time in the field of brain MRI analysis. The results were compared to those presented in a previous study on 28 voxel-based methods in terms of their ability to separate control normal (CN) subjects from the ones diagnosed with AD and MCI. It was observed that our method outperformed all of the others in sensitivity (83.58% in AD/CN and 78.38% in MCI/CN classification) with acceptable specificity values (over 85% in both cases). Furthermore, the method worked for discriminating MCI patients which converted to AD in 18 months (MCIc) from non-converters (MCInc) with a sensitivity outcome better than 27 of 28 methods. Overall, it was shown that the proposed method is promising in early detection of AD.


Meta analysis of alzheimer’s disease at the gene expression level
İzgi, Hamit; Somel, Mehmet; Department of Biology (2017)
In this study, publicly available microarray gene expression datasets are used to investigate common gene expression changes in different postmortem brain regions in Alzheimer’s Disease (AD) patients compared to control subjects, and to find possible functional associations related to these changes. The hypothesis is that pathogenesis of the disease converges into common patterns of dysregulation/alteration or dysfunction in molecular pathways across different brain regions in AD. In total, I studied 13 dat...
Series: The research agenda for general practice/family medicine and primary health care in Europe. Part 4. Results: Specific problem solving skills
Hummers-Pradier, Eva; Beyer, Martin; Chevallier, Patrick; Eilat-Tsanani, Sophia; Lionis, Christos; Peremans, Lieve; Petek, Davorina; Rurik, Imre; Soler, Jean Karl; Stoffers, Henri Ejh; Topsever, Pinar; Ungan, Mehmet; van Royen, Paul (2010-09-01)
The 'Research Agenda for General Practice/Family Medicine and Primary Health Care in Europe ' summarizes the evidence relating to the core competencies and characteristics of the Wonca Europe defi nition of GP/ FM, and its implications for general practitioners/ family doctors, researchers and policy makers. The European Journal of General Practice publishes a series of articles based on this document. The previous articles presented background, objectives, and methodology, as well results on 'primary care ...
Mathematical contributions to dynamics and optimization of gene-environment networks
Weber, Gerhard Wilhelm; Tezel, Aysun; TAYLAN, PAKİZE; Soyler, Alper; Cetin, Mehmet (Informa UK Limited, 2008-01-01)
This article contributes to a further introduction of continuous optimization in the field of computational biology which is one of the most challenging and emerging areas of science, in addition to foundations presented and the state-of-the-art displayed in [C.A. Floudas and P.M. Pardalos, eds., Optimization in Computational Chemistry and Molecular Biology: Local and Global Approaches, Kluwer Academic Publishers, Boston, 2000]. Based on a summary of earlier works by the coauthors and their colleagues, it r...
Ethical Issues in Neuromarketing: "I Consume, Therefore I am!"
IŞIL ÜLMAN, FATMA YEŞİM; Cakar, Tuna; Yildiz, Gokcen (2015-10-01)
Neuromarketing is a recent interdisciplinary field which crosses traditional boundaries between neuroscience, neuroeconomics and marketing research. Since this nascent field is primarily concerned with improving marketing strategies and promoting sales, there has been an increasing public aversion and protest against it. These protests can be exemplified by the reactions observed lately in Baylor School of Medicine and Emory University in the United States. The most recent attempt to stop ongoing neuromarke...
Hippocampal levels of ChAT, PKA, phospho-PKA and phospho-CaMKII alpha but not CaMKII alpha positively correlate with spatial learning skills in rats
Gokcek-Sarac, Cigdem; Adalı, Orhan; Jakubowska-Dogru, Ewa (Elsevier BV, 2013-06-17)
Despite very extensive investigations on molecular processes underlying memory formation, there are very few studies examining potential differences in the brain biochemistry between "good" and "poor" learners belonging to a random population of young animals. In the present study, an attempt was made to correlate individual variation in spatial learning in young-adult Long-Evans rats with hippocampal levels of protein kinase A (PKA), calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha), and ...
Citation Formats
A. Cevik, G.-W. Weber, B. M. Eyüboğlu, and K. K. Oguz, “Voxel-MARS: a method for early detection of Alzheimer’s disease by classification of structural brain MRI,” ANNALS OF OPERATIONS RESEARCH, pp. 31–57, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/39152.