Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Date

2014-08-01

Author

Uysal, Idil
Severcan, FERİDE
Tezcaner, Ayşen
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

105
views

0
downloads

Hydroxyapatite (HA) co-doped with Zn2+ and F ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn2+ and F ions incorporation into HA structure. Co-doping of Zn2+ and F ions decreased unit cell volume of HA and decreased grain sizes. Zn2+ or 5 mol% F- addition into HA significantly Unproved its density. Microhardness was increased with Zn2+ addition and further increase was detected with F- co-doping. Zn2+ and F- co-doped samples had higher fracture toughness than pure HA. Zn2+ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F- addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications. (C) 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.

Subject Keywords

Hydroxyapatite, Co-doping, Microstructure, Microhardness, Biocompatibility

URI

https://hdl.handle.net/11511/39721

Journal

PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL

DOI

https://doi.org/10.1016/j.pnsc.2014.06.004

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

The synthesis of zinc, chloride and fluoride doped nano hydroxylapatites by precipitation method and investigation of their mechanical, structural and biological properties Uysal, İdil; Evis, Zafer; Severcan, Feride; Department of Biomedical Engineering (2011) This study aimed synthesizing hydroxylapatite (HA) and Zn2+, F- and Cl- doped HA by solution precipitation method. The synthesized compounds were sintered at 1100°C for 1h. For structural characterization, density of the samples were measured by Archimedes’ method. It was observed that Zn2+ addition increased the density significantly whereas F- caused a decrease and Cl- increased the density with a little amount. XRD was applied to the samples and it was found that co-doping of Zn2+ and F- ions decreased t...
Silver and fluoride doped hydroxyapatites: Investigation by microstructure, mechanical and antibacterial properties Turkoz, Mustafa; Atilla, Aykan Onur; Evis, Zafer (Elsevier BV, 2013-12-01) Hydroxyapatite co-doped with Ag+ and F- ions was synthesized by the precipitation method and sintered at 1100 degrees C for 1 h. Samples were characterized by density, X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and scanning electron microscopy to investigate their microstructure, phase formation and bonding characteristics. Moreover, samples were also characterized by microhardness and antibacterial tests. Small amount of dopings resulted in high densities and fine grain...
Preparation of lead zirconate by homogeneous precipitation and calcination Oren, EE; Taspinar, E; Tas, AC (1997-10-01) Antiferroelectric PbZrO3 has been synthesized by homogeneous precipitation from aqueous solutions in the presence of urea (NH2CONH2) and calcination for 6 h at 700 degrees C. SEM studies displayed the presence of submicrometer powder, with a significant degree of agglomeration.
Microalloying effects on the microstructure and kinetics of nanoscale precipitation in Ni-Al-Fe alloy Duman, Nagehan; Mehrabov, Amdulla; Akdeniz, Mahmut Vedat (2012-04-01) The aim of this study is to investigate the influence of 3d transition metal (Co, Mn and V) microalloying on the microstructural evolution, thermomagnetic properties and kinetics of nanoscale precipitation in Ni-25Al-25Fe alloy. The three phase solidification microstructure comprising of dendritic beta-phase (ordered bcc) and interdendritic beta + gamma (disordered fcc) + gamma' (ordered fcc) phases in the as-cast state is significantly altered by annealing. Needle-like disordered gamma-phase precipitates a...
Structural and mechanical characteristics of nanohydroxyapatite doped with zinc and chloride Uysal, I.; Severcan, F.; Evis, Zafer (2013-04-01) In this study, hydroxylapatite (HA) doped with Zn2+ and/or Cl- ions was synthesised by precipitation method and sintered at 1100 degrees C for 1 h. Densities of the samples were measured by the Archimedes method. Zn2+ addition increased the density significantly, while Cl- increased the density insignificantly. Hydroxylapatite phase and inconsiderable amount of CaO phase were detected in some samples according to the X-ray diffraction results. Cl- added samples (2.5 mol.-%) increased the hexagonal unit cell...

Citation Formats

I. Uysal, F. Severcan, A. Tezcaner, and Z. Evis, “Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite,” PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, pp. 340–349, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/39721.