Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Date

2014-08-01

Author

Uysal, Idil
Severcan, FERİDE
Tezcaner, Ayşen
Evis, Zafer

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Hydroxyapatite (HA) co-doped with Zn2+ and F ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn2+ and F ions incorporation into HA structure. Co-doping of Zn2+ and F ions decreased unit cell volume of HA and decreased grain sizes. Zn2+ or 5 mol% F- addition into HA significantly Unproved its density. Microhardness was increased with Zn2+ addition and further increase was detected with F- co-doping. Zn2+ and F- co-doped samples had higher fracture toughness than pure HA. Zn2+ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F- addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications. (C) 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.

Subject Keywords

Hydroxyapatite, Co-doping, Microstructure, Microhardness, Biocompatibility

URI

https://hdl.handle.net/11511/39721

Journal

PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL

DOI

https://doi.org/10.1016/j.pnsc.2014.06.004

Collections

Department of Engineering Sciences, Article

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Citation Formats

I. Uysal, F. Severcan, A. Tezcaner, and Z. Evis, “Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite,” PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, pp. 340–349, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/39721.