Organosilanols as Catalysts in Asymmetric Aryl Transfer Reactions

Date

2005-03-01

Author

Özçubukçu, Salih
BOLM, Carsten

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Various ferrocene-based organosilanols have been synthesized in four steps starting from achiral ferrocene carboxylic acid. Applying these novel planar-chiral ferrocenes as catalysts in asymmetric phenyl transfer reactions to substituted benzaldehydes afforded products with high enantiomeric excesses. The best result (91% ee) was achieved in the addition to p-chlorobenzaldehyde with organosilanol 2b, which has a tert-butyl substituent on the oxazoline ring and an isopropyl group on the silanol fragment.

Subject Keywords

Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry

URI

https://hdl.handle.net/11511/41145

Journal

Organic Letters

DOI

https://doi.org/10.1021/ol050242+

Collections

Department of Chemistry, Article

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Citation Formats

S. Özçubukçu and C. BOLM, “Organosilanols as Catalysts in Asymmetric Aryl Transfer Reactions,” Organic Letters, pp. 1407–1409, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41145.