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Organosilanols as Catalysts in Asymmetric Aryl Transfer Reactions
Date
2005-03-01
Author
Özçubukçu, Salih
BOLM, Carsten
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Various ferrocene-based organosilanols have been synthesized in four steps starting from achiral ferrocene carboxylic acid. Applying these novel planar-chiral ferrocenes as catalysts in asymmetric phenyl transfer reactions to substituted benzaldehydes afforded products with high enantiomeric excesses. The best result (91% ee) was achieved in the addition to p-chlorobenzaldehyde with organosilanol 2b, which has a tert-butyl substituent on the oxazoline ring and an isopropyl group on the silanol fragment.
Subject Keywords
Physical and Theoretical Chemistry
,
Organic Chemistry
,
Biochemistry
URI
https://hdl.handle.net/11511/41145
Journal
Organic Letters
DOI
https://doi.org/10.1021/ol050242+
Collections
Department of Chemistry, Article
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S. Özçubukçu and C. BOLM, “Organosilanols as Catalysts in Asymmetric Aryl Transfer Reactions,”
Organic Letters
, pp. 1407–1409, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41145.