MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

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Date

2010-09-01

Author

Somel, Mehmet
Fu, Ning
Yan, Zheng
Hu, Hai Yang
Xu, Ying
Yuan, Yuan
Ning, Zhibin
Hu, Yuhui
Menzel, Corinna
Hu, Hao
Lachmann, Michael
Zeng, Rong
Chen, Wei
Khaitovich, Philipp

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Changes in gene expression levels determine differentiation of tissues involved in development and are associated with functional decline in aging. Although development is tightly regulated, the transition between development and aging, as well as regulation of post-developmental changes, are not well understood. Here, we measured messenger RNA (mRNA), microRNA (miRNA), and protein expression in the prefrontal cortex of humans and rhesus macaques over the species' life spans. We find that few gene expression changes are unique to aging. Instead, the vast majority of miRNA and gene expression changes that occur in aging represent reversals or extensions of developmental patterns. Surprisingly, many gene expression changes previously attributed to aging, such as down-regulation of neural genes, initiate in early childhood. Our results indicate that miRNA and transcription factors regulate not only developmental but also post-developmental expression changes, with a number of regulatory processes continuing throughout the entire life span. Differential evolutionary conservation of the corresponding genomic regions implies that these regulatory processes, although beneficial in development, might be detrimental in aging. These results suggest a direct link between developmental regulation and expression changes taking place in aging.

Subject Keywords

Selection, Transcriptome, Profile, Genomes, Database, Vertebrate, Evolution, Life, Central-nervous-system, Human prefrontal cortex

URI

https://hdl.handle.net/11511/41164

Journal

GENOME RESEARCH

DOI

https://doi.org/10.1101/gr.106849.110

Collections

Department of Biology, Article

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Meta analysis of alzheimer’s disease at the gene expression level İzgi, Hamit; Somel, Mehmet; Department of Biology (2017) In this study, publicly available microarray gene expression datasets are used to investigate common gene expression changes in different postmortem brain regions in Alzheimer’s Disease (AD) patients compared to control subjects, and to find possible functional associations related to these changes. The hypothesis is that pathogenesis of the disease converges into common patterns of dysregulation/alteration or dysfunction in molecular pathways across different brain regions in AD. In total, I studied 13 dat...
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Citation Formats

M. Somel et al., “MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain,” GENOME RESEARCH, pp. 1207–1218, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41164.