Robust background normalization method for one-channel microarrays

Purutçuoğlu Gazi, Vilda
Weber, Gerhard-Wilhelm
Background: Microarray technology, aims to measure the amount of changes in transcripted messages for each gene by RNA via quantifying the colour intensity on the arrays. But due to the different experimental conditions, these measurements can include both systematic and random erroneous signals. For this reason, we present a novel gene expression index, called multi-RGX (Multiple-probe Robust Gene Expression Index) for one-channel microarrays.