Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population

Date

2009-12-01

Author

Demirdogen, Birsen Can
Demirkaya, Seref
Turkanoglu, Aysun
Bek, Semai
Arinc, Emel
Adalı, Orhan

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Background Paraoxonase 1 (PON1) is protective against the development of atherosclerosis. a risk factor for ischemic stroke. PON1 gene has one promoter region (-107T/C) and two coding region (192Q/R and 55L/M) polymorphisms that affect the levels and catalytic efficiency of the enzyme. respectively. In this study. we aimed to determine the importance of -107T/C. 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activity (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke

Subject Keywords

Clinical Biochemistry, Cell Biology, Biochemistry, General Medicine

URI

https://hdl.handle.net/11511/42870

Collections

Department of Biology, Article