A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives

2016-06-01
IŞIK, Murat
Akkoca, H. Ufuk
Akhmedov, I. Mecidoglu
Tanyeli, Cihangir
A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%).

Citation Formats
M. IŞIK, H. U. Akkoca, I. M. Akhmedov, and C. Tanyeli, “A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives,” TETRAHEDRON-ASYMMETRY, vol. 27, pp. 384–388, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/45988.