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A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives

2016-06-01
IŞIK, Murat
Akkoca, H. Ufuk
Akhmedov, I. Mecidoglu
Tanyeli, Cihangir
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%).
Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis
https://hdl.handle.net/11511/45988

Department of Chemistry, Article
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