A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives

Date

2016-06-01

Author

IŞIK, Murat
Akkoca, H. Ufuk
Akhmedov, I. Mecidoglu
Tanyeli, Cihangir

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A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%).

Subject Keywords

Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/45988

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2016.04.001

Collections

Department of Chemistry, Article

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Citation Formats

M. IŞIK, H. U. Akkoca, I. M. Akhmedov, and C. Tanyeli, “A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives,” TETRAHEDRON-ASYMMETRY, pp. 384–388, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/45988.