REGULATION OF BIOSYNTHESIS OF BACILYSIN BY BACILLUS-SUBTILIS

1990-10-01
Özcengiz, Gülay
DEMAIN, AL

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The aspartate pathway of Streptomyces clavuligerus is an important primary metabolic pathway which provides substrates for beta-lactam synthesis. In this study, the hom gene which encodes homoserine dehydrogenase was cloned from the cephamycin C producer S. clavuligerus NRRL 3585 and characterized. The fully sequenced open reading frame encodes 433 amino acids with a deduced M (r) of 44.9 kDa. The gene was heterologously expressed in the auxotroph mutant Escherichia coli CGSC 5075 and the recombinant protei...
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Citation Formats
G. Özcengiz and A. DEMAIN, “REGULATION OF BIOSYNTHESIS OF BACILYSIN BY BACILLUS-SUBTILIS,” JOURNAL OF INDUSTRIAL MICROBIOLOGY, pp. 91–100, 1990, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/46650.