The investigation of leptin and hypothalamic neuropeptides role in first attack psychotic male patients: Olanzapine monotherapy

Sezlev, Deniz
Sutcigil, Levent
Akarsu, Suleyman
Ozgen, Fuat
Yanık, Tülin
The mechanism underlying the weight gain due to treatment with olanzapine and other second generation antipsychotics has not been fully understood. To examine olanzapine's weight gain effects, we accepted first attack psychotic patients with no medication (pre-treatment) (n = 22) and the healthy control group (n = 26) in this study. After patient diagnosis, they were hospitalized and then treated for four weeks with olanzapine (post-treatment). We used case-control association design to test body mass index (BMI) and biochemical changes in each group. We also investigated peripheral leptin and neuropeptides/hormones namely, pro-opiomelanocortin (POMC), cocaine and amphetaime regulated transcript (CART), and neuropeptide Y (NPY) levels. These neuropeptides which are synthesized/secreted from arcuate nucleus of hypothalamus affect food intake and therefore, body weight. After 4 weeks of olanzapine treatment; BMI (body mass index), waist circumference, blood triglyceride, total cholesterol, and very low density lipoprotein (VLDL) levels were increased significantly in patients compared to their pre-treatment baseline. In pre-treatment, patients' NPY levels were significantly lower while alpha-MSH, the anorexigenic product of POMC levels were significantly higher vs. control. Both leptin and NPY levels were significantly increased in patients after the treatment but the NPY levels were also significantly lower in post-treatment vs. the control group. The CART levels did not change after the treatment. We may presume that the antagonist effect of olanzapine on the serotonin (5HT2CR and 5HT1BR) receptors of the arcuate hypothalamic neurons may be a basis for a deregulation of the neurohormones secretion.


Alterations of hypothalamic neuropeptides involved in food intake and appetite in olanzapine monotherapy
Sezlev, Deniz; Yanık, Tülin; Department of Biology (2012)
The mechanism of weight gain due to treatment with olanzapine, a serotonin receptor antagonist, has not been fully understood. Weight gain and food intake are under the control of neuropeptides/hormones, POMC (proopiomelanocortin), CART (cocaine and amphetamine regulated transcript), AgRP (Agouti-related peptide) and NPY (neuropeptide Y) that are synthesized and secreted from the arcuate nucleus (ARC) of hypothalamus. In this study, the altereration of the ARC neuropeptide/hormone levels both in humans and ...
Determination of hypothalamic neuropeptide levels involved in appetite regulation in atypical antipsychotic drug, risperidone treatment
Kurşungöz, Canan; Yanık, Tülin; Department of Biology (2012)
Although the use of atypical antipsychotic drugs is successful in the treatment of schizophrenia, they cause complications in the long term use that is mainly weight gain. In this study, circulating levels of hypothalamic neuropeptides/hormones, which are related to appetite regulation; neuropeptide Y (NPY), alpha melanocyte stimulating hormone (α-MSH), cocaine and amphethamine regulated transcript (CART) and plus leptin in male schizophrenic patients who were treated with an atypical antipsychotic drug, ri...
Impacts of olanzapine coupled with or without metformin administration on the expression of cannabinoid and melanocortin receptors in rats
Jacob Alis, Aditya Kemal; Yanık, Tülin; Department of Biochemistry (2017)
Secondary generation antipsychotics (SGA) were lauded as an improvement over first generation antipsychotics (FGA) in terms of both efficacies and reduced metabolic side effects such as obesity and diabetic phenotypes (1). However, SGAs were still plagued by a plethora of aforementioned metabolic side effects, albeit at reduced severity compared to the FGAs. While the side effects of SGAs had been extensively investigated through different experiments, the exact mechanism of the SGAs on the metabolic disord...
Effects of risperidone treatment on the expression of hypothalamic neuropeptide in appetite regulation in Wistar rats
Kursungoz, Canan; AK, MEHMET; Yanık, Tülin (2015-01-30)
Although the use of atypical antipsychotic drugs has been successful in the treatment of schizophrenia, they can cause some complications in the long-term use, including weight gain. Patients using these drugs tend to disrupt treatment primarily due to side effects. The atypical antipsychotic mechanism of action regulates a number of highly disrupted neurotransmitter pathways in the brains of psychotic patients but may also cause impairment of neurohorrnonal pathways in different brain areas. In this study,...
The Relationship Between Illness Duration And Brain Morphometry in Schizophrenia: Heschl's Gyrus and Prefrontal Cortex Volumetry
KARABAY, NURİ; ÖNİZ, ADİLE; Gökçay, Didem; ALPTEKİN, KÖKSAL; Hugdahl, Kenneth; ÖZGÖREN, MURAT (2013-01-01)
Introduction: The relationship between brain morphology and illness duration has been observed as a biomarker in psychiatric and neurologic patients, especially in schizophrenia. In this study, we aimed to investigate the relationship between the volumes of two target regions [prefrontal cortex (PFC) and Heschl's gyrus (HG)] and illness duration in schizophrenia. Such measurements can have implications for then understanding of cognitive impairments in schizophrenia.
Citation Formats
M. AK, D. Sezlev, L. Sutcigil, S. Akarsu, F. Ozgen, and T. Yanık, “The investigation of leptin and hypothalamic neuropeptides role in first attack psychotic male patients: Olanzapine monotherapy,” PSYCHONEUROENDOCRINOLOGY, pp. 341–347, 2013, Accessed: 00, 2020. [Online]. Available: