İstatistiksel metotlar ile genom-ölçekli protein ağlarının oluşturulması ve analizi

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2010

Author

Söyler, Alper
Can, Tolga
Pamuk, Bahar
Bokar, Awadh H. Ali
Yaveroğlu, Nebil Ömer
Akkoyun, Emrah
Baloğlu, Onur
Turanalp, Emin Mehmet
Güney, Doğacan Tacettin
Yaşar, Sevgi

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Bu projede büyük ölçekli protein-protein etkileşim ağlarının işlemsel metotlar ile tahmin edilmesi ve elde edilen ağların yine işlemsel metotlar ile analiz edilmesi amaçlanmıştır. Proje kapsamında biyologlara ilgilendikleri organizma hakkında sistem biyolojisi seviyesinde bulgular sağlayacak çeşitli teknikler geliştirilmiştir. Özellikle yeni sekanslanmış organizmaları hedefleyen teknikler sayesinde son yıllarda artan sekanslama projelerinden elde edilen verilerin etkili bir şekilde kullanılmasına olanak sağlanmıştır. Sadece protein sekansı kullanılarak protein etkileşimlerinin tahmin edilmesi, büyük ölçekli ağların görselleştirilmesi, ağların işlemsel yollarla otomatik olarak analiz edilerek birbiri ile çok etkileşen protein modüllerinin bulunması ve etkileşim ağlarında sık geçen fonksiyonel örüntülerin bulunması için metotlar geliştirilmiştir. Proje kapsamında geliştirilen metotlar çeşitli yayın ve tezler aracılığıyla bilim dünyasına sunulmuştur. Proje sonucu A. Fumigatus organizması için elde edilen ağ modülleri de ayrıca http://bioserver.ceng.metu.edu.tr/AFumigatus/ adresinde sunulmaktadır.

Subject Keywords

Biyoloji, İstatistik ve Olasılık, Protein-protein etkileşim ağları, İstatistiksel metotlar, Ağ analizi, Ağ görselleştirme, Aspergillus fumigatus

URI

https://app.trdizin.gov.tr/publication/project/detail/T1RVME9Uaz0
https://hdl.handle.net/11511/49404

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Department of Computer Engineering, Project and Design

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Citation Formats

A. Söyler et al., “İstatistiksel metotlar ile genom-ölçekli protein ağlarının oluşturulması ve analizi,” 2010. Accessed: 00, 2020. [Online]. Available: https://app.trdizin.gov.tr/publication/project/detail/T1RVME9Uaz0.