Intramolecular Heterocyclization of O-Propargylated Aromatic Hydroxyaldehydes as an Expedient Route to Substituted Chromenopyridines under Metal-Free Conditions

2015-02-20
Keskin, Selbi
Balcı, Metin
A concise and regioselective approach to the synthesis of chromenopyridine and chromenopyridinone derivatives was developed. The synthetic strategy relies on the O-propargylation of aromatic hydroxyaldehydes followed by reaction with propargylamine. The intramolecular cycloaddition reaction between the alkyne and azadiene, which is formed as an intermediate, furnished the desired skeletons.

Citation Formats
S. Keskin and M. Balcı, “Intramolecular Heterocyclization of O-Propargylated Aromatic Hydroxyaldehydes as an Expedient Route to Substituted Chromenopyridines under Metal-Free Conditions,” ORGANIC LETTERS, vol. 17, no. 4, pp. 964–967, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51017.