Regioselective synthesis of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton: a new class of compound

Date

2009-08-01

Author

Koza, Gani
Ozcan, Sevil
ŞAHİN, Ertan
Balcı, Metin

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We hereby report the first preparation of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton formed by two controlled Curtius rearrangements of the corresponding acyl azides, prepared from 2-(2-methoxy-2-oxoethyl)furan-3-carboxylate via the hydrazide. Rearrangement of the acyl azides followed by trapping by nucleophiles and intramolecular trapping provided the target compounds.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/51306

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2009.05.090

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

G. Koza, S. Ozcan, E. ŞAHİN, and M. Balcı, “Regioselective synthesis of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton: a new class of compound,” TETRAHEDRON, pp. 5973–5976, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51306.