Fourier Transform Infrared Spectroscopic Studies of Diabetic Rat Heart Crude Membranes

Download

10.1155:2003:472834.pdf

Date

2003

Author

Severcan, Feride
Kaptan, Nese
Turan, Belma

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

152
views

134
downloads

Application of mid infrared spectroscopy in diabetic tissues will be presented which highlight the promise of this technique in medical research. Examples presented mainly will focus on diabetic rat heart crude membranes. Diabetes mellitus (DM) was induced in rats by streptozotocin (STZ) injection that is one of the most popular experimental models for the study of type I diabetes. The shift in the peak positions, bandwidths and the intensity of the bands in FTIR spectra were analyzed to have valuable structural and functional information, which may have diagnostic value. In the diabetic membranes significant increase was observed in lipid order and lipids concentration. While the concentration of saturated lipids increases, the concentration of unsaturated lipids decreases. In addition, broadening of the amide I bands and the appearance of the new band around 1640 cm−1together with the decrease in the amide I to amide II ratio indicate the structural changes occurring in proteins of diabetic membranes. A dramatic increase in oligosaccarite band (1042 cm−1) and a decrease in olefinic stretching band (3012 cm−1), were also observed.

Subject Keywords

Diabetes, Heart membrane, FTIR

URI

https://hdl.handle.net/11511/51741

Journal

Spectroscopy

DOI

https://doi.org/10.1155/2003/472834

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Prediction of renal respiratory motion for compensation during percutaneous needle insertion in robot assisted surgery Çetinkaya, Mehmet; Erkmen, Aydan Müşerref; Department of Electrical and Electronics Engineering (2018) In this study, the aim is to design a respiratory motion prediction algorithm which can be used to compensate for this physiological disturbance in medical operations where respiration limits operation accuracy. For this purpose, a new Kalman filter has been developed for tracking quasi-periodic signals approximated as finite Fourier series. Instead of relying on approximations provided by Extended Kalman Filter or Unscented Kalman Filter, our filter performs the exact calculation of the mean and covariance...
Coordinate transformation aided finite element method for contour detection of breast tumors in microwave imaging ÖZGÜN, ÖZLEM; Kuzuoğlu, Mustafa (2018-10-01) A coordinate transformation based finite element method is presented for detecting contours of breast cancer tissues in the context of microwave imaging. The geometry and location of a single or multiple cancerous tumors inside a breast tissue are identified by constructing an inverse problem based on the genetic optimization algorithm. The expensive forward solution phase during repeated cost function evaluations is accelerated by placing a transformation medium inside the finite element mesh. This allows ...
Adaptive multivariate solution schemes for inverse electrocardiography problem Onak, Önder Nazım; Serinağaoğlu Doğrusöz, Yeşim; Weber, Gerhard Wilhelm; Department of Scientific Computing (2018) Electrocardiographic Imaging (ECGI) is an emerging medical imaging modality to visualizetheheart’selectricalactivity. Ithasapromisingpotentialfordiagnosingcardiac abnormalities and facilitate the planning and execution of necessary treatments. Visualizing heart’s electrical activity requires solving the ill-posed inverse electrocardiography (ECG) problem. Despite the considerable efforts and improvements in this ﬁeld, there exist some limitations and challenges that hinder its application to daily clinical ...
Computational modeling of growth: systemic and pulmonary hypertension in the heart Rausch, M. K.; Dam, A.; Göktepe, Serdar; Abilez, O. J.; Kuhl, E. (2011-12-01) We introduce a novel constitutive model for growing soft biological tissue and study its performance in two characteristic cases of mechanically induced wall thickening of the heart. We adopt the concept of an incompatible growth configuration introducing the multiplicative decomposition of the deformation gradient into an elastic and a growth part. The key feature of the model is the definition of the evolution equation for the growth tensor which we motivate by pressure-overload-induced sarcomerogenesis. ...
Automatic segmentation of human facial tissue by MRI-CT fusion: A feasibility study Kale, Emre H.; Mumcuoğlu, Ünal Erkan; HAMCAN, Salih (2012-12-01) The aim of this study was to develop automatic image segmentation methods to segment human facial tissue which contains very thin anatomic structures. The segmentation output can be used to construct a more realistic human face model for a variety of purposes like surgery planning, patient specific prosthesis design and facial expression simulation. Segmentation methods developed were based on Bayesian and Level Set frameworks, which were applied on three image types: magnetic resonance imaging (MRI), compu...

Citation Formats

F. Severcan, N. Kaptan, and B. Turan, “Fourier Transform Infrared Spectroscopic Studies of Diabetic Rat Heart Crude Membranes,” Spectroscopy, pp. 569–577, 2003, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51741.