Effect of cisplatin treatment on protein expression of vitamin D metabolizing CYP24A1 in PC3 cell line

Date

2018-07-01

Author

Evin, Emre
Akkulak, Merve
Adalı, Orhan

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URI

https://hdl.handle.net/11511/52523

Journal

FEBS OPEN BIO

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Department of Biology, Article

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Effect of quercetin on mRNA and protein expressions of vitamin D metabolizing CYP27B1 and CYP24A1 in human embryonic kidney cell line (HEK-293) Durukan, Özlem; Akkulak, Merve; Özhan, Güneş; Evin, Emre; Adalı, Orhan (Wiley, 2018-07-01) Vitamin D is essential compound for life having role not only in the regulation of calcium metabolism but also in the regulation of cell proliferation, immune responses, cardiovascular homeostasis and nervous system. These wide range of actions occur with the enzymatic conversion of vitamin D to 1a,25-dihydroxyvitamin D by cytochrome P450 enzymes (CYPs). While CYP27B1 provides the synthesis of hormonally active form of Vitamin D, 1,25(OH)2D, CYP24A1 involves in catabolism of vitamin D. Quercetin, as one of ...
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Citation Formats

E. Evin, M. Akkulak, and O. Adalı, “Effect of cisplatin treatment on protein expression of vitamin D metabolizing CYP24A1 in PC3 cell line,” FEBS OPEN BIO, pp. 326–326, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52523.