Effect of phytoestrogen emodin on doxorubicin-induced cytotoxicity and apoptosis on tumorigenic MCF-7 and non-tumorigenic MCF-10A human breast cells

Güray, Nülüfer Tülün


Effect of hydrogenation conditions on rheological and micro-structural properties of fats
Başkoçak, Altuğ; Mert, Behiç; Department of Food Engineering (2011)
Hydrogenation is one of the most applied techniques in the fats and oils industry to produce wide range of hardened fats with different physical and chemical properties. Each different combination of hydrogenation conditions serves products of different rheological and micro-structural properties. Therefore, the purpose of this study is to examine the effect of different industrially available catalysts on rheological and micro-structural properties of hydrogenated fats. Three different catalysts were used ...
Effect of surface modification of rice straw on mechanical and flow properties of TPU-based green composites
Tayfun, Umit; DOĞAN, Mehmet; Bayramlı, Erdal (2016-05-01)
In this study, rice straw (RS) which was one of the major agricultural residues was used as filler in bio-based thermoplastic polyurethane (TPU). Several treatments including hot water, alkali, permanganate, peroxide and silane were applied for modifying the surface of RS. The effects of surface modifications on mechanical, flow, morphological, and water absorption properties of green composites were investigated at a constant 30 wt% RS loading. Silane treatment performed after alkaline treatment gave the h...
Effect of emodin on doxorubicin-induced cytotoxicity and apoptosis on MCF-7 and MCF-10a cells
Kaya, Bade; Güray, Tülin; Uyar, Pembegül; Department of Biology (2014)
Emodin (3-Methyl-1,6,8-trihydroxyanthraquinone), is a phytoestrogenic component of Rheum and Polygonum plant extracts which has been used to treat several diseases since ancient times. It has been shown to have anti-microbial, anti-oxidant and anti-cancer effects in nature. The anti-tumor drug doxorubicin, a widely used chemotherapeutic agent, is used for the treatment of many cancer types including lung, gastric, ovarian and breast cancer. In this study, the effects of pre-, co- and alone treatment of doxo...
Effect of doxorubicin on telomerase activity and apoptotic gene expression in doxorubicin-resistant and -sensitive MCF-7 cells
Eskiocak, Ugur; Iseri, Ozlem Darcansoy; Kars, Meltem Demirel; Bicer, Atilla; Gündüz, Ufuk (2008-01-01)
Background: Dose-and time-dependent effects of doxorubicin on telomerase activity ( TA) and expression levels of hTERT, Bcl-2, Bcl-x(L) and Bax were investigated in doxorubicin-resistant and -sensitive MCF-7 cells. Methods: Doxorubicin-resistant MCF-7/R was developed from sensitive MCF-7 breast carcinoma cell line and acquired resistance was demonstrated by XTT and mRNA analysis of MDR1 and MRP1 genes. Expression levels were determined by RT-PCR. Newly developed rapid and simple TRAP-silver staining assay w...
Effect of gelatinization properties of different starch types in the presence of psyllium fiber on in vitro digestion
Sevilmiş, Başak; Şensoy, İlkay; Department of Food Engineering (2021-2-12)
Starch’s digestibilityin foods strongly depends on the structure, other ingredients,and processing conditions used. It is essentialto understand the relationship between food matrix and starch digestibility. Theaimwasto investigate the effect of psyllium fiber on gelatinization, crystallinity, and in vitrodigestibility of starches with different crystalline structures (A, B,and C). Starches from variousbotanical sources (wheat, potato, and tapioca) with and without added psyl...
Citation Formats
P. UYAR, B. KAYA, and N. T. Güray, “Effect of phytoestrogen emodin on doxorubicin-induced cytotoxicity and apoptosis on tumorigenic MCF-7 and non-tumorigenic MCF-10A human breast cells,” 2014, vol. 281, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52734.