Conjugation of gemcitabine to PAMAM dendrimer-coated magnetic nanoparticles for targeted delivery

Parsian, M.
PourianAzar, N. Taghavi
Yalcin, S.
Mutlu, Pelin
Gündüz, Ufuk


Preparation of silica coated cobalt ferrite magnetic nanoparticles for the purification of histidine-tagged proteins
Aygar, Gülfem; Volkan, Mürvet; Özkan, Necati; Department of Micro and Nanotechnology (2011)
The magnetic separation approach has several advantages compared with conventional separation methods; it can be performed directly in crude samples containing suspended solid materials without pretreatment, and can easily isolate some biomolecules from aqueous systems in the presence of magnetic gradient fields. This thesis focused on the development of new class of magnetic separation material particularly useful for the separation of histidine-tagged proteins from the complex matrixes through the use of ...
Comparison of two polymeric nanocarriers for targeted CpG-ODN delivery: chitosan- and poly (amidoamine) dendrimer-coated magnetic nanoparticles
Pourianazar, N. Taghavi; Parsian, M.; Unsoy, G.; Yalcin, S.; Gündüz, Ufuk (2014-09-01)
Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines
Yalcin, Serap; Erkan, Mert; Unsoy, Gozde; Parsian, Maryam; Kleeff, Jorg; Gündüz, Ufuk (2014-07-01)
Gemcitabine is an anticancer drug used in the treatment of different cancer types, including pancreatic ductal adenocarcinoma. The maximum tolerated dose in humans is restricted by its side effects on healty cells. Furthermore, the fibrotic stroma produced by the pancreatic stellate cells prevents effective delivery of chemotherapeutic agents providing a safe-haven for the cancer cells. This becomes more of a problem considering the short half-life of this drug. Magnetic nanoparticle-based targeted drug del...
Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery
PARSIAN, MARYAM; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2016-12-30)
Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an advantage for selective drug targeting as they can be targeted to the tumor site and accumulated in cancer cells by means of an external magnetic field. Magnetic nanoparticles can be coated with Polyamidoamine (PAMAM) dendrimer and loaded with drugs. However, biomedical applications of PAMAM ...
Conjugation effects on carrier mobilities of polythiophenes probed by time-resolved terahertz spectroscopy
Esentürk, Okan; Deongchamp, Dean M.; Heilweil, Edwin J. (American Chemical Society (ACS), 2008-07-24)
Optically generated carrier conductivity of thiophene-based spin-cast polymer films, as cast poly(3-hexylthiophene) (P3HT) and both as cast and above liquid crystalline temperature annealed poly(2,5-bis(3tetradecylthiophen-2yl)thieno[3,2-b]thiophene) (PBTTT), were measured by time-resolved THz spectroscopy (TRTS) and compared to reported thin-film transistor (TFT) device measurements. The relative mobilities of the samples measured by TRTS agree well with reported TFl` mobilities. Since TRTS is sensitive to...
Citation Formats
M. Parsian, N. T. PourianAzar, S. Yalcin, P. Mutlu, and U. Gündüz, “Conjugation of gemcitabine to PAMAM dendrimer-coated magnetic nanoparticles for targeted delivery,” 2014, vol. 281, Accessed: 00, 2020. [Online]. Available: