CXCL16 influences the nature and specificity of CpG DNA-induced immune activation

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2006-06-01

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Gürsel, Mayda

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https://hdl.handle.net/11511/53353

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CXCL16 influences the nature and specificity of CpG-induced immune activation. Gürsel, Mayda; Mostowski, HS; Klinman, DM (2006-08-01) Unmethylated CpG motifs are present at high frequency in bacterial DNA. They provide a danger signal to the mammalian immune system that triggers a protective immune response characterized by the production of Th1 and proinflammatory cytokines and chemokines. Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. This work establishes that CXCL...
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Citation Formats

M. Gürsel, “CXCL16 influences the nature and specificity of CpG DNA-induced immune activation,” 2006, vol. 273, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/53353.