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CHNQ EXERTS ANTITUMOR ACTIVITY AGAINST COLORECTAL CANCER THROUGH THE INDUCTION OF APOPTOSIS AND OXIDATIVE STRESS
Date
2015-06-12
Author
Enayat, Shabnam
Ceyhan, Muşerref
Son, Çağdaş Devrim
Stefek, Milan
Banerjee, Sreeparna
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https://hdl.handle.net/11511/86853
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CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo
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Quercetin (Qc) shows strong antitumor effects but has limited clinical application due to poor water solubility and bioavailability. In a screening of novel semi-synthetic derivatives of Qc, 3,7-dihydroxy-2-[4-(2-chloro-1,4-naphthoquinone-3-yloxy)-3-hydroxyphenyl]-5-hydroxychromen-4-one (CHNQ) could ameliorate acetic acid induced acute colitis in vivo more efficiently than Qc. Since inflammation contributes to colorectal cancer (CRC), we have hypothesized that CHNQ may have anti-cancer effects. Using CRC ce...
CHFR-associated early G(2)/M checkpoint defects in breast cancer cells
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Cell division is a highly regulated process. Checkpoints can halt cell-cycle progression due to adverse conditions such as misalignment of chromosomes to prevent missegregation. The search for new regulators of the cell cycle revealed the mitotic checkpoint gene CHFR (checkpoint with forkhead-associated and ring finger). CHFR coordinates an early mitotic phase by delaying chromosome condensation in response to a mitotic stress. Because aneuploidy and chromosome instability are common in malignant breast tum...
RanGTP induces an effector gradient of XCTK2 and importin alpha/beta for spindle microtubule cross-linking
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High RanGTP around chromatin is important for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects of importin alpha/beta Here we examine how the Ran gradient regulates Kinesin-14 function to control spindle organization. We show that Xenopus Kinesin-14, XCTK2, and importin alpha/beta form an effector gradient that is highest at the poles and diminishes toward the chromatin, which is opposite the RanGTP gradient. Importin alpha and beta preferentially inhibit XCTK2 antip...
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Chiral amines are important starting materials for the synthesis of biologically important compounds. Enantioselective addition of dialkylzinc reagents to imines is a reliable method for the synthesis of these compounds. Different chiral catalysts were developed and used for this method. Phosphorous based PFAM catalysts were tried for the first time in the enantioselective synthesis of amines by reacting diethylzinc with N-sulfonyl imines and N-diphenylphosphinoyl imines. Chiral amines were isolated with mo...
SNX3 LOSS ENHANCES EGFR OVEREXPRESSION IN A MOUSE TRIPLE NEGATIVE BREAST CANCER MODEL
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Sorting nexin 3 (SNX3) is one of the sorting nexin family proteins and recruits the retromer complex in endosomal trafficking. SNX3 binds specifically to Phosphotidylinositol3Phosphate (PtdIns(3)P) via its Phox-domain (PX) domain but can also interact with cargo proteins which are mostly membrane receptors. Internalized receptors can be recycled back to the plasma membrane or the trans Golgi network or degraded in lysosomes or proteosomes. In addition to the role of SNX3 in Wntless (Wls) and Transferr...
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S. Enayat, M. Ceyhan, Ç. D. Son, M. Stefek, and S. Banerjee, “CHNQ EXERTS ANTITUMOR ACTIVITY AGAINST COLORECTAL CANCER THROUGH THE INDUCTION OF APOPTOSIS AND OXIDATIVE STRESS,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/86853.