CXCL16 influences the nature and specificity of CpG-induced immune activation.

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2006-08-01

Author

Gürsel, Mayda
Mostowski, HS
Klinman, DM

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Unmethylated CpG motifs are present at high frequency in bacterial DNA. They provide a danger signal to the mammalian immune system that triggers a protective immune response characterized by the production of Th1 and proinflammatory cytokines and chemokines. Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. This work establishes that CXCL16, a membrane-bound scavenger receptor, influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. This is the first example of a surface receptor modifying the cellular specificity and nature of the immune response mediated by an intracellular TLR.

Subject Keywords

Induction, Identification, Expression, Chemokine, Dna, Cutting edge, Cellular uptake, Scavenger receptor, Nonspecific cytotoxic-cells, Toll-like receptor-9

URI

https://hdl.handle.net/11511/32981

Journal

Journal of immunology (Baltimore, Md. : 1950)

DOI

https://doi.org/10.4049/jimmunol.177.3.1575

Collections

Department of Biology, Article

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Citation Formats

M. Gürsel, H. Mostowski, and D. Klinman, “CXCL16 influences the nature and specificity of CpG-induced immune activation.,” Journal of immunology (Baltimore, Md. : 1950), pp. 1575–80, 2006, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32981.