Dempster-Schafer Method in Family Based Association Studies

Date

2012-11-03

Author

Rajabli, Farid
Goktas, Unal
İnan, Gül

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

198
views

0
downloads

In experiments designed for family-based association studies, methods such as transmission disequilibrium test (TDT) require large number of trios to identify single nucleotide polymorphisms (SNPs) associated with the disease. However, unavailability of large number of trios is the Achilles' heel of many complex disease studies, especially for the late-onset diseases since parents might have passed away or unavailable. This problem motivated us to look for new approaches that require smaller number of trios to detect associations in family based studies. Aiming this, we propose using Dempster-Shafer method of evidence to detect the associations in family-based studies and show that this approach has a good performance in identifying associations with moderate to small sized samples.

Subject Keywords

Single nucleotide polymorphisms, Tansmission disequilibrium test, Dempster-Shafer, Algorithm, Genetics, Transmission disequilibrium test, Dempster-Shafer

URI

https://hdl.handle.net/11511/54018

Collections

Department of Statistics, Conference / Seminar

Suggestions

OpenMETU
Core

Application of Dempster-Schafer Method in Family-Based Association Studies Rajabli, Farid; Goktas, Unal; İnan, Gül (2013-07-01) In experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has ...
Systems-level analysis of genome wide association study results for a pilot juvenile idiopathic arthritis family study Aydın Son, Yeşim; Demirkaya, Erkan; BİLGİNER, YELDA; KASAPÇOPUR, Özgür; Unsal, Erbil; ALİKAŞİFOĞLU, MEHMET; ÖZEN, SEZA (2015-01-01) Genome wide association studies (GWAS) determine susceptibility profiles for complex diseases. In this study, GWAS was performed in 26 patients with oligo and rheumatoid factor negative polyarticular juvenile idiopathic artritis (JIA) and their healthy parents by Affymetrix 250K SNP arrays. Biological function and pathway enrichment analysis was done. This is the first GWAS reported for JIA families from the eastern Mediterranean population. Enrichment of Fc gamma R-mediated phagocytosis pathway and respons...
Investigation of the impacts of linkage disequilibrium on SNP selection studies Kantar Özçırpan, Ekin; Weber, Gerhard Wilhelm; İyigün, Cem; Department of Biomedical Engineering (2015) In many Genome Wide Association Studies (GWAS), the relation between SNPs and complex diseases has being tried to reveal. Moreover it is known that, in GWAS there exist a high amount of data which include relations between SNPs, phenotypes and diseases, etc. Many algorithms have been used to be able to reach the desired information from this huge data. Therefore, in this study, an algorithm one of whose important steps is based on linkage disequilibrium(LD), was constructed to eliminate the redundant inform...
Investigation of cellular responses in a patient with STAT1 gain-of-function mutation successfully transplanted with Ruxolitinib bridge therapy and characterization of anti-viral immune responses in DOCK8 deficiency Kayaoğlu, Başak; Muyan, Mesut; Department of Biology (2023-1) Gain-of-function mutations (GOF) in the STAT1 gene are associated with impaired STAT1 phosphorylation/dephosphorylation cycle and Th17 deficiency. A sporadic T835M mutation in the STAT1 gene was detected in a patient with chronic mucocutaneous candidiasis (CMC), viral and bacterial infections accompanied by autoimmunity. Here, we aimed to investigate the cellular level defects in the patient and how they were affected by Ruxolitinib treatment and hematopoietic stem cell transplantation (HSCT). We showed tha...
Dna repair genes, xrcc3 and rad51, polymorphisms and risk of childhood acute lymphoblastic leukemia Tanrıkut, Cihan; Arınç, Emel; Çoruh, Nursen; Department of Biochemistry (2010) In this study, the role of two DNA repair genes, X-ray repair cross complementing group 3 (XRCC3) Thr241Met and Rad51 G135C polymorphisms were investigated in the risk of development of childhood ALL in Turkish population among 193 healthy controls and 184 ALL patients, by using PCR-RFLP technique. For XRCC3 Thr241Met polymorphism, the frequencies of both heterozygous and homozygous mutant genotypes were found to be higher in the controls compared to ALL patients (OR: 0.59, p = 0.02; OR: 0.48, p = 0.02, res...

Citation Formats

F. Rajabli, U. Goktas, and G. İnan, “Dempster-Schafer Method in Family Based Association Studies,” 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54018.