Expression of multidrug resistance 1, lung resistance protein and breast cancer resistance protein genes in chronic lymphocytic and chronic myelogeneous leukemia.

Ural, A. Ugur
Iseri, Ozlem Darcansoy
Mutlu, Pelin
Kars, Meltem Demirel
Avcu, Ferit
Gündüz, Ufuk
Ilhan, Osman


A photodynamic pathway to apoptosis induced by hypericin in human myeloma ARH-77 cell line: Possible relevance to photodynamic therapy.
Avcu, F; Ural, AU; Baran, Y; Sobaci, G; Deveci, M; Cetin, T; Pekel, A; Sarper, M; Elci, P; Gündüz, Ufuk (2005-11-16)
The low frequency of defective TPMT alleles in Turkish population: A study on pediatric patients with acute lymphoblastic leukemia
Tumer, Tugba Boyunegmez; Ulusoy, Gulen; Adalı, Orhan; Sahin, Gurses; Gozdasoglu, Sevgi; Arinc, Ennel (Wiley, 2007-10-01)
6-Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are the major determinants of interindividual differences in the severe toxicity or efficacy of 6MP Four variant alleles, TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3C, are responsible over the 80% of low or undetectable enzyme activity. The frequencies of these variants were investigated among 106 children with ALL in Turkish population. TPM...
Expression of the potential biomarker heat shock protein 70 and its regulator, the metazoan DnaJ homolog, by temperature stress in the sponge Geodia cydonium
Koziol, C; Batel, R; Arinc, E; Schroder, HC; Muller, WEG (Inter-Research Science Center, 1997-01-01)
Because sponges (Porifera) are generally the dominant group of multicellular animals found in the marine benthos they are key animals for the testing of biomarkers in this biotope. Previously, it was shown that the heat shock protein hsp70 from the marine sponge Geodia cydonium is a useful biomarker for following biological responses to selected physical and chemical stressors. One protein which is critical for hsp70 function in other organisms is the DnaJ-like protein. In this study we therefore isolated a...
Anti-Cancer Effects of Clofazimine As a Single Agent and in Combination with Cisplatin in Multiple Myeloma
Durusu, Ipek; Hüsnügil, Hepşen Hazal; Atas, Heval; Biber, Aysenur; Gerekci, Selin; Gulec, Aliye Ezgi; Özen, Can (2016-12-02)
Multiple Myeloma (MM) is a malignant neoplasm of bone marrow plasma B cells with high morbidity. Clofazimine (CLF) is an FDA-approved leprostatic, anti-tuberculosis, and anti-inflammatory drug that was previously shown to have growth suppression effect on various cancer types such as hepatocellular, lung, cervix, esophageal, colon, and breast cancer as well as melanoma, neuroblastoma, and leukemia. The objective of this study was to evaluate the anticancer effect and mechanism of CLF on U266 MM cell line. C...
Role hydrology, sewage effluent diversion and fish on mass balance of nutrients in a system of shallow lakes Mogan and Eymir, Turkey
Karapınar, Burcu; Beklioğlu, Meryem; Department of Biology (2005)
In this study, annual total phosphorus (TP) budget and dissolved inorganic nitrogen (DIN) load were constructed for Lakes Mogan and Eymir for the period of eight years from 1997 to 2004 and the period of ten years covering from 1993 to 1995 and 1997 to 2004, respectively. Lake Mogan experienced seasonal and interannual water level fluctuations. Low water level experienced in 2001 led to decrease in the in-lake TP amount whereas 2-fold increase in the in-lake DIN amount was recorded. Also, high hydraulic res...
Citation Formats
A. U. Ural et al., “Expression of multidrug resistance 1, lung resistance protein and breast cancer resistance protein genes in chronic lymphocytic and chronic myelogeneous leukemia.,” 2006, vol. 108, Accessed: 00, 2020. [Online]. Available: