The Structural Investigation of Protective Role of Antiepileptic Vigabatrin in Epilepsy Treatment by FTIR Spectroscopy and Neural Networks

Turker, S.
Severcan, M.
Severcan, Feride


Simultaneous purification and characterization of cytochrome b5 reductase and cytochrome b5 from sheep liver
Arinc, E; Cakir, D (Elsevier BV, 1999-02-01)
Cytochrome b5 was purified from detergent solubilized sheep liver microsomes by using three successive DEAE-cellulose, and Sephadex G-100 column chromatographies. It was purified 54-fold and the yield was 23.5% with respect to microsomes. The apparent Mr of cytochrome b5 was estimated to be 16,200 +/- 500 by SDS-PAGE. Absolute absorption spectrum of the purified cytochrome b5 showed maximal absorption at 412 nm and dithionite-reduced cytochrome b5 gave peaks at 557, 526.5 and 423 nm. The ability of the puri...
Monitoring of Radioprotective Effects of Amifostine on Rat Liver Microsomal Membrane and Brain Tissue Lipids by FTIR Spectroscopy and Microspectroscopy.
Cakmak, G.; Miller, L. M.; Severcan, M.; Zorlu, F.; Severcan, Feride (2011-01-01)
Evaluation of colloidal platinum on cytotoxicity, oxidative stress and barrier permeability across the gut epithelium
Tuncer, Sinem; Colakoglu, Melis; Ulusan, Sinem; Ertaş, Gülay; KARASU, Çimen; Banerjee, Sreeparna (2019-03-01)
Colloidal platinum (Pt) is widely consumed due to its health promoting benefits. However, the exact biological effects of these nanoparticles have not been studied in detail, particularly in the gut. In the present study we observed that colloidal Pt was not cytotoxic towards three different epithelial colon cancer cell lines. Co-treatment of the colon cancer cell line Caco-2 with the oxidative stress inducing agent hydrogen peroxide (H2O2) and colloidal Pt resulted in a significant decrease in H2O2 induced...
The effect of cysteine-43 mutation on thermostability and kinetic properties of citrate synthase from Thermoplasma acidophilum
Kocabıyık, Semra; Russel, RJM; Danson, MJ; Hough, DW (Elsevier BV, 1996-07-05)
In this study, we have substituted serine-43 by cysteine in the recombinant citrate synthase from a moderately thermophilic Archaeon Thermoplasma acidophilum, for site-specific attachment of labels and have investigated the effects of this mutation on the biochemical properties and thermal stability of the enzyme. Both wild-type and the mutant enzymes were purified to homogenity using affinity chromatography on Matrex Gel Red A. The mutant Thermoplasma citrate synthase is very similar to wild-type citrate s...
Effects of Commercial Formula Feeding in a Fasting Animal Model: A Fourier Transform Infrared Spectroscopic Study
Dogan, A.; Tuzlaci, A.; Guvenc, B.; Severcan, Feride (2006-01-01)
Citation Formats
S. Turker, M. Severcan, S. KOMSUOĞLU, and F. Severcan, “The Structural Investigation of Protective Role of Antiepileptic Vigabatrin in Epilepsy Treatment by FTIR Spectroscopy and Neural Networks,” 2011, vol. 22, Accessed: 00, 2020. [Online]. Available: