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Controlled release of bioactive agents in gene therapy and tissue engineering
Date
2003-01-01
Author
Keskin, DS
Hasırcı, Vasıf Nejat
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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Even though the drugs are effective in the treatment of some diseases, they may be inefficient or incapable of solving the problem in some other diseases. It is known that some diseases have genetic causes and therefore the search for a therapy in these cases is intense. The solutions involving either direct application of a gene or its basic product, proteins, especially the growth factors, are oftencontemplated. Gene therapy is a novel approach to treating diseases based on modifying the expression of a person’s genes toward a therapeutic goal. While genes and proteins offer a great opportunity for the treatment of many diseases their administration require critical consideration of the structure and conditions. When the conventional methods of drug administration is adopted for the administration of genes and proteins the results are not successful. Genetic material and the proteins are too labile or unstable due to their fragile 3-D structures and this makes their administration to a medium for long periods in unprotected form impossible. For gene delivery in vivo, additional problems have to be overcome, including the anatomical size constraints, protection from nonspecific interactions with body fluids, extracellular matrix and nontarget cells.
Subject Keywords
Delivery
,
Complexes
,
Polymer
,
Bone
,
Copolymers
,
Adenovirus
,
Prospects
,
Systems
,
Design
,
Growth
,
Gene therapy
,
Tissue engineering
,
Gene delivery
,
Tissue engineer
,
Tissue engineering application
URI
https://hdl.handle.net/11511/55223
Journal
TISSUE ENGINEERING, STEM CELLS AND GENE THERAPIES
Collections
Graduate School of Natural and Applied Sciences, Article