Idiophatic generalized epilepsy and gamma amino butyric acid (GABA) B1 receptor genetic polymorphisms (G1465a and C59T) in Turkish population

Demirdogen, B. C.
Eroglu, E.
Micoogullari, Y.
Bek, S.
Adalı, Orhan


Cytochrome P4501A1 genotypes and smoking- and hypertension-related ischemic stroke risk
Demirdöğen, B. Can; Adali, A.Ç.; Bek, S.; Demirkaya, Ş.; Adalı, Orhan (SAGE Publications, 2012-10-30)
This study aimed to determine whether the coding (A4889G) and noncoding region (T6235C) polymorphisms of the gene coding for cytochrome P4501A1 (CYP1A1), a xenobiotic-metabolizing enzyme responsible for the metabolism of carcinogenic polycyclic aromatic hydrocarbons, are involved in the pathogenesis of ischemic stroke in Turkish population. Study group consisted of 226 ischemic stroke patients and 113 controls. Genotypes were attained by allele-specific polymerase chain reaction (PCR) for A4889G and PCR/res...
Analysis of cytochrome P4501A1 genetic polymorphisms in patients with ischemic stroke
Adalı, Ayşe Çınar; Adalı, Orhan; Demirdöğen, Birsen Can; Department of Biochemistry (2011)
Stroke is the third leading cause of death worldwide and results in serious disabilities. Cytochrome P450 1A1 gene (CYP1A1) is a highly polymorphic gene encoding its corresponding xenobiotic metabolizing enzyme which is responsible from the metabolism of carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are engaged with the formation of free radicals. Atherosclerosis is a major cause of ischemic stroke and this pathology may be associated with the disruption of vascular homeostasis due to the format...
Association between gamma aminobutyric acid (GABA) type B receptors gene polymorphisms and idiopathic generalized epilepsy
Eroğlu, Ezgi; Adalı, Orhan; Demirdöğen, Birsen Can; Department of Biology (2011)
Epilepsy is neurological disorder affecting 0.5 to 1% of the population all around the world. It is characterized by the seizures, which are the sudden alterations of behavior due to a temporary change in electrical functioning of the brain. Idiopathic generalized epilepsy (IGE) accounts for one-fifth of all the other epilepsy types, and several gene mutations were identified as the causes of IGE. In general, voltage-gated and ligand-gated ion channel mutations are linked with seizure formation. Gamma amino...
Gravitating instantons in 3 dimensions
Ferstl, A; Tekin, Bayram; Weir, V (2000-09-15)
We study the Einstein-Chern-Simons gravity coupled to Yang-Mills-Higgs theory in three-dimensional Euclidean space with a cosmological constant. The classical equations reduce to Bogomol'nyi type first order equations in curved space. There are BPS type gauge theory instanton (monopole) solutions of finite action in a gravitational instanton which itself has a finite action. We also discuss gauge theory instantons in the vacuum (zero action) AdS space. In addition we point out to some exact solutions which ...
The determinants of life satisfaction in Post-Soviet Azerbaijan
Galip, Hilal; Akçay, Ali Adnan; Department of Sociology (2008)
The study aims to investigate main determinants of life satisfaction in newly independent country, Azerbaijan. Taking into consideration of local and cultural characteristics of the region, this research will give the opportunity for making cross-cultural analysis to understand subjective well-being of people living in the country in transition. Moreover, it provides deeper interpretation of daily experiences of people in different fields of life compared to Soviet period. In the survey, 1030 households wer...
Citation Formats
B. C. Demirdogen, E. Eroglu, Y. Micoogullari, S. Bek, and O. Adalı, “Idiophatic generalized epilepsy and gamma amino butyric acid (GABA) B1 receptor genetic polymorphisms (G1465a and C59T) in Turkish population,” Seville, SPAIN, 2012, vol. 279, Accessed: 00, 2020. [Online]. Available: