Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study

van Os, Jim
Pries, Lotta-Katrin
Delespaul, Philippe
Kenis, Gunter
Luykx, Jurjen J.
Lin, Bochao D.
Richards, Alexander L.
Akdede, Berna
Binbay, Tolga
Yalincetin, Berna
Cihan, Burçin
Soyguer, Haldun
Cankurtaran, Eylem Sahin
Kaymak, Semra Ulusoy
Mihaljevic, Marina M.
Petrovic, Sanja Andric
Mirjanic, Tijana
Bernardo, Miguel
Cabrera, Bibiana
Bobes, Julio
Saiz, Pilar A.
Garcia-Portilla, Maria Paz
Sanjuan, Julio
Aguilar, Eduardo J.
Santos, Jose Luis
Jimenez-Lopez, Estela
Arrojo, Manuel
Carracedo, Angel
Lopez, Gonzalo
Gonzalez-Penas, Javier
Parellada, Mara
Maric, Nadja P.
Atbasoglu, Cem
Ucok, Alp
Arango, Celso
O'Donovan, Michael
Rutten, Bart P. F.
Guloksuz, Sinan
Background First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. Methods We conducted, using two different samples for discovery (n= 336 controls and 649 siblings of patients with psychotic disorder) and replication (n= 1208 controls and 1106 siblings), an analysis of association between PRS on the one hand and psychopathological and cognitive intermediate phenotypes of schizophrenia on the other in a sample at average genetic risk (healthy controls) and a sample at higher than average risk (healthy siblings of patients). Two subthreshold psychosis phenotypes, as well as a standardised measure of cognitive ability, based on a short version of the WAIS-III short form, were used. In addition, a measure of jumping to conclusion bias (replication sample only) was tested for association with PRS. Results In both discovery and replication sample, evidence for an association between PRS and subthreshold psychosis phenotypes was observed in the relatives of patients, whereas in the controls no association was observed. Jumping to conclusion bias was similarly only associated with PRS in the sibling group. Cognitive ability was weakly negatively and non-significantly associated with PRS in both the sibling and the control group. Conclusions The degree of endophenotypic expression of schizophrenia polygenic risk depends on having a sibling with psychotic disorder, suggestive of underlying gene-environment interaction. Cognitive biases may better index genetic risk of disorder than traditional measures of neurocognition, which instead may reflect the population distribution of cognitive ability impacting the prognosis of psychotic disorder.


Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
Guloksuz, Sinan; et. al. (Wiley, 2019-06-01)
Schizophrenia is a heritable complex phenotype associated with a background risk involving multiple common genetic variants of small effect and a multitude of environmental exposures. Early twin and family studies using proxy-genetic liability measures suggest gene-environment interaction in the etiology of schizophrenia spectrum disorders, but the molecular evidence is scarce. Here, by analyzing the main and joint associations of polygenic risk score for schizophrenia (PRS-SCZ) and environmental exposures ...
Psychometric properties of the Hamilton Depression Rating Scale and other physician-rated psychiatric scales for the assessment of depression in ESRD patients undergoing hemodialysis in Turkey
Gençöz, Faruk; Gençöz, Tülin (Informa UK Limited, 2007-08-01)
This study aimed to examine the reliability and validity of clinician-rated psychiatric scales for end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) treatment in Turkey. For this, the Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Global Assessment of Functioning (GAF) Scale, Clinical Global Impression (CGI) Scale, and Mini Mental State Exam (MMSE) were administered to 45 ESRD outpatients undergoing HD treatment. Regarding the reliability of HDRS and HARS, ...
Sociodemographic/clinical characteristics and risk factors associated with chronic tic disorders
Tural Hesapçioǧlu, Selma; Tural, Mustafa Kemal; KANDİL, SEMA (Turkish Association of Nervous and Mental Health, 2013-01-01)
Objective: This study aimed to investigate comorbidity, and sociodemographic and clinical characteristics in children and adolescents with Tourette's syndrome (TS) and chronic motor or vocal tic disorder (CMVTD), and to determine the predictors of tic disorders. Materials and Methods: In all, 57 children and adolescents with TS and CMVTD were compared with a control group. Data were obtained using the Yale Global Tic Severity Scale (YGTSS), Turgay DSM-IV-Based Disruptive Behavioral Disorders Screening and ...
Factors associated with the symptoms of depression and anxiety among male Turkish prisoners: a life crisis and personal growth model perspective
ŞENOL DURAK, EMRE; Gençöz, Faruk (Informa UK Limited, 2010-01-01)
The factors associated with depression and anxiety disorders in the prison populations have been empirically tested in various studies. The aim of the present study was to examine the factors associated with the symptoms of depression and anxiety in a sample of 179 Turkish male prisoners. For this purpose, a model conceptualized by Schaefer and Moos (1998) was used as the theoretical framework for this study. The role of locus of control (as a personality trait); prison type, crime type, time spent in priso...
SAHIN, NH; SAHIN, N (Wiley, 1992-03-01)
The Dysfunctional Attitude Scale (DAS-A) has been used in many studies to measure depressogenic attitudes, vulnerability to depression and to assess the effectiveness of cognitive therapy. Despite its frequent use in research, no data have yet been reported on its item validity. The purpose of the present study was to investigate the item validity and psychometric properties of the DAS-A in the Turkish cultural context. The subjects were 345 university students. The locally adapted versions of the Beck ...
Citation Formats
J. van Os et al., “Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study,” PSYCHOLOGICAL MEDICINE, pp. 1884–1897, 2020, Accessed: 00, 2020. [Online]. Available: