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Modeling gene regulatory networks with piecewise linear differential equations
Date
2007-09-16
Author
Gebert, J.
Radde, N.
Weber, Gerhard Wilhelm
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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Microarray chips generate large amounts of data about a cell's state. In our work we want to analyze these data in order to describe the regulation processes within a cell. Therefore, we build a model which is capable of capturing the most relevant regulating interactions and present an approach how to calculate the parameters for the model from time-series data. This approach uses the discrete approximation method of least squares to solve a data fitting modeling problem. Furthermore, we analyze the features of our proposed system, i.e., which kinds of dynamical behaviors the system is able to show.
Subject Keywords
Management Science and Operations Research
,
Modelling and Simulation
,
Information Systems and Management
URI
https://hdl.handle.net/11511/56789
Journal
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
DOI
https://doi.org/10.1016/j.ejor.2005.11.044
Collections
Graduate School of Applied Mathematics, Article