Prosigna assay for treatment decisions in early breast cancer: A single center, decision impact study

2019-02-01
Esin, E.
Oksuzoglu, B. O.
Markoc, F.
Bilgetekin, I.
Yildiz, F.
Guntekin, S.
Yukruk, F.
Atalay, Rengül

Suggestions

APA isoform diversity in triple negative breast cancers
AKMAN TUNCER, HESNA BEGÜM; ÖYKEN, MERVE; AĞUŞ, HIZLAN HINCAL; Erdem, Murat; Çiçek, Esra; Can, Tolga; Erson Bensan, Ayşe Elif (2017-04-05)
Alternative polyadenylation (APA) plays a role in gene expression regulation generally by shortening of 3'UTRs and relieving microRNA-mediated repression. Therefore, APA is gaining increased attention as a potential mechanism to activate oncogenes. Owing to high proliferative indices of triple negative breast cancers (TNBCs), we hypothesized APA to cause 3'UTR length changes in this aggressive subgroup of breast cancers. Our probe-based meta-analysis approach identified 3'UTR length alterations where the si...
Investigation of a mechanistic link between 15-Lipoxygenase-1 (15-LOX-1) and Metastasis Associated Protein 1 (MTA1) in human colorectal carcinoma cell lines
ÇAĞATAY, SİBEL; Banerjee, Sreeparna (2013-09-01)
Background: Metastasis Associated Protein 1 (MTA1) is a member of the nuclear remodeling and histone deacetylase (NuRD) complex that is known to repress the expression of several tumor suppressor genes. 15-lipoxygenase-1 (15-LOX-1), a member of the inflammatory eicosanoid pathway, has been shown by us and others to have an anti-tumorigenic role in colon cancer. ALOX15 was recently shown to be repressed by the NuRD complex. Previously we have reported that ectopic expression of 15-LOX-1 in colon cancer cells...
A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma
Kahraman, Deniz Cansen; TOZKOPARAN KÖPRÜCÜ, BİRSEN; Atalay, Rengül (2019-07-01)
Hepatocellular carcinoma (HCC) is the fifth most common and the second lethal cancer worldwide. HCC is resistant to conventional chemotherapy and radiotherapy due to its highly heterogenous structure. Therefore, it is crucial to design and develop novel therapeutic strategies against HCC. Non-steroidal anti-inflammatory drugs (NSAIDs) have long been studied for the treatment of acute and chronic conditions with pain and inflammation. In recent years, evidence from various studies suggested that NSAIDs reduc...
RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells.
Puverel, S; Kiriş, Erkan; Singh, S; Klarmann, KD; Coppola, V; Keller, JR; Tessarollo, L (Impact Journals, LLC, 2016-12-20)
c-Kit is a tyrosine kinase receptor important for gametogenesis, hematopoiesis, melanogenesis and mast cell biology. Dysregulation of c-Kit function is oncogenic and its expression in the stem cell niche of a number of tissues has underlined its relevance for regenerative medicine and hematopoietic stem cell biology. Yet, very little is known about the mechanisms that control c-Kit protein levels. Here we show that the RanBPM/RanBP9 scaffold protein binds to c-Kit and is necessary for normal c-Kit protein e...
Bioactivities of novel boehmeriasin derivatives in liver cancer cells
Guzelcan, E. Akhan; Baumann, M.; Baxendale, I.; Atalay, Rengül (2016-07-01)
Citation Formats
E. Esin et al., “Prosigna assay for treatment decisions in early breast cancer: A single center, decision impact study,” 2019, vol. 79, p. 0, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/63036.