An application of topological median filters on detection and clustering of microcalcifications in digital mammograms

Cihan, Ibrahim Kivanc
Senel, Hakan Guray
Existence of microcalcification clusters on mammograms is one of the earliest signs of breast cancers. In this study, a method that is based on topological median filters is proposed for the automated detection of microcalcifications. The proposed algorithm consists of two steps. First, probable microcalcification pixels in the mammograms are segmented out by using topological top-hat transform. Then, individual microcalcifications are clustered by using a subtractive clustering algorithm. The method has been applied to Nijmegen database of 34 mammograms with a total of 72 microcalcification clusters. The results show that the proposed algorithm has a success rate of 93%.


Investigation of microRNAs on genomic instability regions in breast cancer
Selçuklu, Şadan Duygu; Erson Bensan, Ayşe Elif; Department of Biology (2007)
Genomic instability is commonly seen in breast cancers. To date, various chromosomal or segmental loss or amplification regions have been detected in primary tumors and cell lines. Hence, an intensive search for potent tumor suppressors or oncogenes located in these regions continues. MicroRNAs (miRNAs) are ~18-24 nt long non-coding RNAs that regulate protein expression either by target mRNA cleavage or translational repression. We hypothesized that miRNAs located in genomic instability regions in breast ca...
An investigation of microRNAs mapping to breast cancer related genomic gain and loss regions
Selcuklu, S. D.; Yakicier, M. C.; Erson Bensan, Ayşe Elif (Elsevier BV, 2009-02-01)
Various regions of amplification or loss are observed in breast tumors as a manifestation of genomic instability. To date, numerous oncogenes or tumor suppressors on some of these regions have been characterized. An increasing body of evidence suggests that such regions also harbor microRNA genes with crucial regulatory roles in cellular processes and disease mechanisms, including cancer. Here, we investigated 35 microRNAs localized to common genomic gain and/or loss regions in breast cancers. To examine am...
Modeling of Breast and Gynecological Cancers Data and Investigating New Biological Findings
Ağyüz, Umut; Purutçuoğlu Gazi, Vilda (null; 2018-06-27)
The breast and gynecological cancers are two most common fatal cancers’ types in women in the world [1]. In oncological literature, these two cancers types are typically worked together since they are the risk factors of each other if the patient has one of these diseases [2]. In general, the cancers, like the heart diseases, are the systems’ ilnesses in the sense that any malfunctions in the associated transaction pathways cause problems in the activation flow, resulting in tumors. Therefore, the mathemati...
Comparison of NAT1, NAT2 & GSTT2-2 activities in normal and neoplastic human breast tissues
Geylan-SU, YS; Isgor, B; Coban, T; Kapucuoglu, N; Aydintug, S; Iscan, M; Iscan, M; Güray, Nülüfer Tülün (American Society for Pharmacology & Experimental Therapeutics (ASPET), 2006-01-01)
In this study, arylamine N-acetyltransferases, NATs (E.C. and glutathione-S-transferase-T2-2, GSTT2-2 (E.C. enzyme activities in the breast tumor and surrounding tumor-free tissues of 22 female breast cancer patients with infiltrating ductal carcinoma were measured. The possible impacts of grade of malignancy, chemotherapy treatment, estrogen receptor status and menopausal status on all enzyme activities were evaluated. The results showed that, both NAT2 and GSTT2-2 display significant diff...
Theoretical assessment of electro-thermal imaging: A new technique for medical diagnosis
Carlak, H. Feza; Gençer, Nevzat Güneri; Beşikci, Cengiz (Elsevier BV, 2016-05-01)
Breast cancer is one of the most crucial cancer types. To improve the diagnosis performance, a hybrid system is proposed through simultaneous utilization of thermal and electrical impedance imaging methods. The innovation of the approach relies on the frequency dependence of the tissue's electrical impedance which facilitates the acquisition of multiple thermal images with currents at different frequencies injected to the region of the body under inspection. The applied current and the resulting heating at ...
Citation Formats
I. K. Cihan and H. G. Senel, “An application of topological median filters on detection and clustering of microcalcifications in digital mammograms,” 2006, p. 2384, Accessed: 00, 2020. [Online]. Available: