Comparison of NAT1, NAT2 & GSTT2-2 activities in normal and neoplastic human breast tissues

Download

index.pdf

Date

2006-01-01

Author

Geylan-SU, YS
Isgor, B
Coban, T
Kapucuoglu, N
Aydintug, S
Iscan, M
Iscan, M
Güray, Nülüfer Tülün

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

196
views

0
downloads

In this study, arylamine N-acetyltransferases, NATs (E.C.2.3.1.5) and glutathione-S-transferase-T2-2, GSTT2-2 (E.C.2.5.1.18) enzyme activities in the breast tumor and surrounding tumor-free tissues of 22 female breast cancer patients with infiltrating ductal carcinoma were measured. The possible impacts of grade of malignancy, chemotherapy treatment, estrogen receptor status and menopausal status on all enzyme activities were evaluated. The results showed that, both NAT2 and GSTT2-2 display significant differences between tumor and tumor-free breast tissues, while no difference was observed in NAT1. Grade of malignancy seems to be positively associated with NAT1 and negatively associated with GSTT2-2. Though, both NAT2 and GSTT2-2 have increased mean tumor activities, the grade of malignancy, chemotherapy status, menopausal status or estrogen receptor status are not correlated statistically.

Subject Keywords

Pharmacology, Pharmaceutical Science

URI

https://hdl.handle.net/11511/37502

Journal

NEOPLASMA

DOI

https://doi.org/10.1124/dmd.108.023564

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Prospective evaluation of Vitamin K2, Raloxifene and their co-administration in osteoporotic rats Tasci, A. G.; BİLGİLİ, HASAN; Altunay, H.; Gecit, M. R.; Keskin, Dilek (Elsevier BV, 2011-07-17) In this study, therapeutic effects of Vitamin K2, Raloxifene and their co-administration on bone, uterus, blood and weight profiles were investigated with an ovariectomized rat model. Forty Wistar rats were divided into five groups (n = 8): Raloxifene (R), Vitamin K2 (K), Raloxifene + Vitamin K2 (R + K), ovariectomized controls (OVX) and Sham-operated controls (Sham). Treatment began 3 months after ovariectomy. Vitamin K2 and Raloxifene were administered 30 and 1.5 mg/kg/day separately and in combination fi...
Comparison of GST Isoenzyme Expression in Normal and Neoplastic Breast Tissue: Correlation with Clinical and Prognostic Factors OĞUZTÜZÜN, SERPİL; İşcan, Mesude; ÖZHAVZALI, MÜZEYYEN; Sak, Serpil Dizbay (2009-01-01) Glutathione S-transferases in breast tissue play an important role in the susceptibility to the mutagenic effects of chemical carcinogens and in the response of breast tumors to chemotherapy. In this study the immunohistochemical staining characteristics of glutathione S-transferase isoenzymes (alpha, mu, pi, and theta) were investigated in invasive duct carcinomas and in normal breast tissue of 43 patients. The relationships between the expression of the GST isoenzymes and some clinicopathological features...
Biomechanical and histological outcome of combined raloxifene-estrogen therapy on skeletal and reproductive tissues Tasci, Arzu; BİLGİLİ, HASAN; Altunay, Hikmet; Gecit, Mehmet Rusen; Keskin, Dilek (Elsevier BV, 2010-02-10) Estrogen replacement is a potent therapy for postmenopausal osteoporosis. However, its carcinogenic effects on breasts and the uterus limit its utilization. Raloxifene has estrogen-like effects on bones without the carcinogenic symptoms on breast or uterine tissue. Their individual effects are well characterized, but the results of their interaction remains elusive. In this work, we investigate the consequences of a combined raloxifene/estrogen therapy on bone and uterus with experimental osteoporosis. 40 W...
CALCULATION OF AVERAGE GLANDULAR DOSES IN PATIENTS UNDERGOING MAMMOGRAPHY Ege, Ahmet; Kestel, Sevtap Ayşe; Department of Biomedical Engineering (2021-9-09) The mean absorbed radiation dosage by the breast glandular tissue in mammography is called the "Average Glandular Dose" (AGD). The latest ICRP (International Comission on Radiological Protection) publication on the use of DRLs (Diagnostic Reference Level) in medical imaging recommends the AGD as DRL values. Diagnostic mammogram data about doses were collected for 253 healthy women between 40 to 64 years of ages with 1012 screenings completed in one calendar year in a medical institution in Turkey. Local DRL...
Camptothecin Anticancer Drug Loaded Iron Oxide Micro and Nanoparticles: Tuning Targeted and Sustained Release of the Drug in Bioactive Form Gokduman, Kurtulus; Demir, Ayhan Sıtkı (Bentham Science Publishers Ltd., 2013-12-01) Although Camptothecin (CPT) has significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers; lactone ring opening causes a reduction in cytotoxic activity and severe side effects in physiological conditions (pH: 7.4, 37 degrees C) due to decreased cell membrane binding, membrane diffusibility, and intrinsic potency against the topoisomerase target. Taken into consideration the targeted delivery advantage of biocompatible magnetic particles, in order to contribute to the removal of...

Citation Formats

Y. Geylan-SU et al., “Comparison of NAT1, NAT2 & GSTT2-2 activities in normal and neoplastic human breast tissues,” NEOPLASMA, pp. 73–78, 2006, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37502.