Comparison of collagen biomatrix and omentum effectiveness on peripheral nerve regeneration

Cemil, Berker
Ture, Durukan
Cevirgen, Banu
Kaymaz, Figen
Kaymaz, Memduh
Despite the presence of various nerve coaptation materials and techniques, achievement of the functional nerve regeneration is still inadequate. This study was aimed to compare the effectiveness of conduit composed of collagen biomatrix and omentum graft on peripheral nerve regeneration. Thirty-five male Wistar rats were divided into four groups. In the control group, the right sciatic nerve was skeletonized from the sciatic notch till the point of bifurcation. In the primary epineural repair group, the nerve was transected 1 cm proximal to the bifurcation with a sharp pair of micro scissors and then repaired with four epineural sutures. In the collagen biomatrix group, the epineural repaired nerve was wrapped with collagen biomatrix. In the collagen group, the epineural repaired nerve was wrapped with the nonpediculated omentum. Assessment of the nerve regeneration was based on functional (Walking Track Analysis, Electrophysiological Measurements), histological, and morphometric criteria. Light and electron microscopic examinations showed that collagen-biomatrix-wrapped specimens have the best regeneration. The electrophysiological study confirmed the recovery of electrical activity in the regenerated axons.


Contact guidance enhances the quality of a tissue engineered corneal stroma
Vrana, E.; Builles, N.; Hindie, M.; Damour, O.; AYDINLI, ATİLLA; Hasırcı, Vasıf Nejat (2008-02-01)
Corneal stroma is a very complex structure, composed of 200 lamellae of oriented collagen fibers. This highly complex nature of cornea is known to be important for its transparency and mechanical integrity. Thus, an artificial cornea design has to take into account this complex structure. In this study, behavior of human corneal keratocytes on collagen films patterned with parallel channels was investigated. Keratocytes proliferated well on films and reached confluency after 7 days in the incubation medium....
Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair.
Arslantunalı Şahin, Damla; Hasırcı, Vasıf Nejat (2014-03-01)
A nerve conduit is designed to improve peripheral nerve regeneration by providing guidance to the nerve cells. Conductivity of such guides is reported to enhance this process. In the current study, a nerve guide was constructed from poly(2-hydroxyethyl methacrylate) (pHEMA), which was loaded with multiwalled carbon nanotubes (mwCNT) to introduce conductivity. PHEMA hydrogels were designed to have a porous structure to facilitate the transportation of the compounds needed for cell nutrition and growth and al...
Tissue engineered cartilage on collagen and PHBV matrices
Kose, GT; Korkusuz, F; Ozkul, A; Soysal, Y; Ozdemir, T; Yildiz, C; Hasırcı, Vasıf Nejat (2005-09-01)
Cartilage engineering is a very novel approach to tissue repair through use of implants. Matrices of collagen containing calcium phosphate (CaP-Gelfix (R)), and matrices of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) were produced to create a cartilage via tissue engineering. The matrices were characterized by scanning electron microscopy (SEM) and electron diffraction spectroscopy (EDS). Porosity and void volume analysis were carried out to characterize the matrices. Chondrocytes were isola...
Evaluation of Threshold Values for Root Canal Filling Voids in Micro-CT and Nano-CT Images
Orhan, Kaan; Jacobs, Reinhilde; Celikten, Berkan; Huang, Yan; de Faria Vasconcelos, Karla; Nicolielo, Laura Ferreira Pinheiro; Buyuksungur, Arda; Van Dessel, Jeroen (Hindawi Limited, 2018-7-16)
While several materials and techniques have been used to assess the quality of root canal fillings in micro-CT images, the lack of standardization in scanning protocols has produced conflicting results. Hence, the aim of this study was to determine a cutoff voxel size value for the assessment of root canal filling voids in micro-CT and nano-CT images. Twenty freshly extracted mandibular central incisors were used. Root canals were prepared with nickel titanium files to an ISO size 40/0.06 taper and then fil...
Estimation of Ground Reaction Forces Using Low-Cost Instrumented Forearm Crutches
Seylan, Çağlar; Saranlı, Uluç (2018-06-01)
Instrumented crutches are useful for many rehabilitation tasks, including monitoring the correctness of crutch use, analyzing gait properties for patients with lower-limb impairments, as well as providing sensory data for controlling lower-body robotic orthoses. In this paper, we describe the design and analysis of an instrumented crutch system equipped with low-cost accelerometer and pressure sensors to estimate all components of the ground reaction force (GRF), providing a well-defined and physically mean...
Citation Formats
B. Cemil, D. Ture, B. Cevirgen, F. Kaymaz, and M. Kaymaz, “Comparison of collagen biomatrix and omentum effectiveness on peripheral nerve regeneration,” NEUROSURGICAL REVIEW, pp. 355–362, 2009, Accessed: 00, 2020. [Online]. Available: