Neuropathic insult increases the responsiveness to acetic acid in mice

Date

2019-09-01

Author

Gurdap, Cenk O.
Markwalter, Patrick S.
Neddenriep, Bradley
Bagdas, Deniz
Damaj, M. Imad

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Chronic neuropathic pain is a burden to millions of patients every day. Patients with neuropathic pain will also experience acute pain throughout their everyday lives adding to their nociceptive burden. Using nociceptive models in mice this study aimed to investigate the relationship between acute visceral pain and chronic neuropathic pain in spontaneous and affective behaviors. Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve of C57BL/6J male mice and examined in assays of acetic acid (AA)-induced stretching or conditioned place aversion to assess nociceptive and aversive behaviors. Stretching induced by a low concentration (0.32%) of AA given intraperitoneally was significantly increased in CCI and paclitaxel-treated animals compared to control animals. A higher concentration (1.2%) of AA was able to induce stretching equally in both neuropathic and control mice. In the conditioned place aversion test, an AA concentration of 0.32% did not induce place aversion in either sham or CCI animals. However, the 1.2% concentration of AA-induced higher place aversion scores in CCI mice compared to sham mice. No difference in place conditioning was observed between paclitaxel and vehicle-treated mice. Overall, our results show that peripheral nerve injury and paclitaxel treatment induces hypersensitivity to AA-induced nociception and place aversion. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.

Subject Keywords

Pharmacology, Psychiatry and Mental health

URI

https://hdl.handle.net/11511/67978

Journal

BEHAVIOURAL PHARMACOLOGY

DOI

https://doi.org/10.1097/fbp.0000000000000486

Collections

Department of Biology, Article

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Citation Formats

C. O. Gurdap, P. S. Markwalter, B. Neddenriep, D. Bagdas, and M. I. Damaj, “Neuropathic insult increases the responsiveness to acetic acid in mice,” BEHAVIOURAL PHARMACOLOGY, pp. 534–537, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67978.