Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal

Date

2020-07-01

Author

VARAN, CEM
Anceschi, Anastasia
Sevli, Serhat
Bruni, Natascia
Giraudo, Leonardo
BİLGİÇ, ELİF
KORKUSUZ, PETEK
Iskit, Alper B.
Trotta, Francesco
BİLENSOY, EREM

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Cyclodextrin-based nanosponges (CD-NS) are considered as safe and biocompatible systems for removing toxic molecules from the body. Rapid removal of toxic molecules that are formed in the body from certain food constituents, is relevant especially for patients affected by chronic kidney disease. Within the scope of this study, innovative cyclodextrin polymers were synthesized to form nanosponges able to remove indole, before it could form the toxic indoxyl sulfate in the body. Furthermore, in vivo studies were carried out using the two optimal CD-NS formulations by assessing physicochemical properties, stability, indole adsorption capacity and in vitro cytotoxicity. NS prepared from beta-cyclodextrin cross-linked with toluene diisocyanate was found to be the most effective NS with an in vitro indole adsorption capacity of over 90%. In addition, this derivative was more stable in gastrointestinal media. Animal studies further revealed that oral CD-NSs did not tend to accumulate and damage gastrointestinal tissues and are excreted from the GI tract with minimal absorption. In conclusion, this study suggests that CD-NS formulations are effective and safe in removing toxic molecules from the body. Their potential use in veterinary or human medicine could reduce dialysis frequency and avoid hepatic and cardiac toxicity avoiding the indole formation.

Subject Keywords

Pharmaceutical Science

URI

https://hdl.handle.net/11511/68533

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS

DOI

https://doi.org/10.1016/j.ijpharm.2020.119485

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Citation Formats

C. VARAN et al., “Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal,” INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68533.