Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal

Anceschi, Anastasia
Sevli, Serhat
Bruni, Natascia
Giraudo, Leonardo
Iskit, Alper B.
Trotta, Francesco
Cyclodextrin-based nanosponges (CD-NS) are considered as safe and biocompatible systems for removing toxic molecules from the body. Rapid removal of toxic molecules that are formed in the body from certain food constituents, is relevant especially for patients affected by chronic kidney disease. Within the scope of this study, innovative cyclodextrin polymers were synthesized to form nanosponges able to remove indole, before it could form the toxic indoxyl sulfate in the body. Furthermore, in vivo studies were carried out using the two optimal CD-NS formulations by assessing physicochemical properties, stability, indole adsorption capacity and in vitro cytotoxicity. NS prepared from beta-cyclodextrin cross-linked with toluene diisocyanate was found to be the most effective NS with an in vitro indole adsorption capacity of over 90%. In addition, this derivative was more stable in gastrointestinal media. Animal studies further revealed that oral CD-NSs did not tend to accumulate and damage gastrointestinal tissues and are excreted from the GI tract with minimal absorption. In conclusion, this study suggests that CD-NS formulations are effective and safe in removing toxic molecules from the body. Their potential use in veterinary or human medicine could reduce dialysis frequency and avoid hepatic and cardiac toxicity avoiding the indole formation.


SENER, E; TURGUT, H; YALCIN, I; OREN, I; Türker, Burhan Lemi; CELEBI, N; AKIN, A (Elsevier BV, 1994-09-19)
The synthesis and in vitro antimicrobial activity of 5-substituted 2-(3-pyridyl)benzoxazoles (3-7) is described for some Gram-positive and Gram-negative bacteria and the yeast Candida albicans. The compounds 3-7 exhibited significant activity against the screened microorganisms, having MIC values between 25 and 12.5 mu g/ml. Quantum-chemical calculations were performed for the compounds 1-10, in order to observe some feasible structure-activity relationships. These theoretical observations, calculated for t...
GOKER, H; ERTAN, R; AKGUN, H; YULUG, N (Wiley, 1991-05-01)
Synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. Structures of the compounds were elucidated with IR-, H-1-NMR-, C-13-NMR-, mass-spectra and elemental analysis. Preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100-mu-g/ml against Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis.
Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development
Bayyurt, Banu; Tincer, Gizem; Almacioglu, Kubra; Alpdundar, Esin; Gürsel, Mayda; GÜRSEL, İHSAN (Elsevier BV, 2017-02-10)
Nucleic acid-based Toll-like receptor (TLR) ligands are promising adjuvants and immunotherapeutic agents. Combination of TLR ligands potentiates immune response by providing synergistic immune activity via triggering different signaling pathways and may impact antigen dependent T-cell immune memory. However, their short circulation time due to nuclease attack hampers their clinical performance. Liposomes offer inclusion of protein and nucleic acid-based drugs with high encapsulation efficiency and drug load...
The immunological co-adjuvant action of liposomal interleukin-2: The role of mode of localisation of the cytokine and antigen in the vesicles
Gürsel, Mayda (Informa UK Limited, 1998-01-01)
In experiments designed to study the co-adjuvant action of interleukin-2, a model antigen (tetanus toroid) was passively entrapped in, or covalently coupled to multilamellar liposomes in the presence or absence of interleukin-2 (IL-2). When present, IL-2 was either co-entrapped with the toroid, entrapped alone in liposomes with toroid coupled to their surface, or coupled to the surface of liposomes with entrapped toroid. The role of spatial localization of IL-2 within the liposomal structure (vis a vis that...
Use of Fenton oxidation to improve the biodegradability of a pharmaceutical wastewater
Tekin, Huseyin; BİLKAY, Okan; Ataberk, Selale S.; Balta, Tolga H.; Ceribasi, I. Haluk; Sanin, Faika Dilek; Dilek, Filiz Bengü; Yetiş, Ülkü (2006-08-21)
The applicability of Fenton's oxidation to improve the biodegradability of a pharmaceutical wastewater to be treated biologically was investigated. The wastewater was originated from a factory producing a variety of pharmaceutical chemicals. Treatability studies were conducted under laboratory conditions with all chemicals (having COD varying from 900 to 7000 mg/L) produced in the factory in order to determine the operational conditions to utilize in the full-scale treatment plant. Optimum pH was determined...
Citation Formats
C. VARAN et al., “Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal,” INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: