Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B

Karatayli, Senem C.
Bozdayi, Mithat
Karatayli, Ersin
Ozturk, Tugba
Husseini, Abbas A.
Albayrak, Rabia
Ozkan, Muhip
Kalaylioglu, Zeynep
Cinar, Kubilay
Yurdaydin, Cihan
Background & AimsAim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL-28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development of HBeAg-negative CHB vs. inactive HBsAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV patients was also used to see if they behave differently compared to chronic HBV patients.


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Abstract In this study, the effect of homologous multiple copies of the ask gene, which encodes aspartokinase catalyzing the first step of the aspartate pathway, on cephamycin C biosynthesis in S. clavuligerus NRRL 3585 and its hom mutant was investigated. The intracellular pool levels of aspartate pathway amino acids accorded well with the Ask activity levels in TB3585 and AK39. When compared with the control strain carrying vector alone without any gene insert, amplification of the ask gene in the w...
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In this study, an algorithm named ClustOrth is proposed for determining and matching functionally orthologous protein clusters in different species. The algorithm requires protein interaction networks of the organisms to be compared and GO terms of the proteins in these interaction networks as prior information. After determining the functionally related protein groups using the Repeated Random Walks algorithm, the method maps the identified protein groups according to the similarity metric defined. In orde...
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Citation Formats
S. C. Karatayli et al., “Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B,” LIVER INTERNATIONAL, pp. 846–853, 2015, Accessed: 00, 2020. [Online]. Available: