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Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B

Karatayli, Senem C.
Bozdayi, Mithat
Karatayli, Ersin
Ozturk, Tugba
Husseini, Abbas A.
Albayrak, Rabia
Ozkan, Muhip
Kalaylioglu, Zeynep
Cinar, Kubilay
Yurdaydin, Cihan
Background & AimsAim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL-28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development of HBeAg-negative CHB vs. inactive HBsAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV patients was also used to see if they behave differently compared to chronic HBV patients.