Targeted delivery of PEI:DNAoligo complexes with PLGA nanocapsules to bone tissue

Sezlev Bilecen, Deniz
Rodrıguez Cabello, Jose Carlos
Uludağ, Hasan
Hasırcı, Vasıf Nejat
22nd International Biomedical Science and Technology Symposium (12 - 14 Mayıs 2017)


Targeted delivery of CPG-oligodeoxynucleotide to breast cancer cells by poly-amidoamine dendrimer-modified magnetic nanoparticles
Taghavi Pourianazar, Negar; Gündüz, Ufuk; Gündüz, Güngör; Department of Biotechnology (2016)
One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...
Targeted silencing of Survivin in cancer cells by siRNA loaded chitosan magnetic nanoparticles
ÜNSOY, GÖZDE; Gündüz, Ufuk (2016-01-01)
Background: The aim of this study was to silence Survivin expression, related with drug-resistance, via siRNA-loaded CS-MNPs.
Targeted disruption of homoserine dehydrogenase gene in Streptomyces clavuligerus and its effects on cephamycin C production
Çaydaşı (Koca), Ayşe; Özcengiz, Gülay; Department of Biology (2006)
The members of the genus Streptomyces are well-known for their capacity to synthesize a vast repertoire of secondary metabolites, including many useful antibiotics and proteins. Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics such as cephamycin C and the potent β-lactamase inhibitor clavulanic acid. The aspartate pathway of S. clavuligerus is an important primary metabolic pathway providing substrates for β-lactam synthesis. This pathway uses L-aspartic acid as the ...
Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus
Yilmaz, Ebru I.; Caydasi, Ayse K.; Özcengiz, Gülay (Springer Science and Business Media LLC, 2008-01-01)
The aspartate pathway of Streptomyces clavuligerus is an important primary metabolic pathway which provides substrates for beta-lactam synthesis. In this study, the hom gene which encodes homoserine dehydrogenase was cloned from the cephamycin C producer S. clavuligerus NRRL 3585 and characterized. The fully sequenced open reading frame encodes 433 amino acids with a deduced M (r) of 44.9 kDa. The gene was heterologously expressed in the auxotroph mutant Escherichia coli CGSC 5075 and the recombinant protei...
Targeted liposomes for cell death imaging and amplified drug delivery
RİCE, Douglas; Türkyılmaz, Serhan; PALUMBO, Rachael; HARMATYS, Kara; SMİTH, Bradley D (2013-03-02)
The goal is to develop liposomes that have selective affinity for dead and dying cells, and then use the liposomes as targeted imaging agents for rapidly assessing the efficacy of anticancer therapies. A subsequent application is to use the liposomes to deliver anticancer drugs to tumors and initiate cell death processes that amplify the liposome targeting at later time points in the therapy. The liposome surface is decorated with 2% Zn-DPA-PEG2000-PE, an anchored phospholipid with an extended polyethylene ...
Citation Formats
D. Sezlev Bilecen, J. C. Rodrıguez Cabello, H. Uludağ, and V. N. Hasırcı, “Targeted delivery of PEI:DNAoligo complexes with PLGA nanocapsules to bone tissue,” presented at the 22nd International Biomedical Science and Technology Symposium (12 - 14 Mayıs 2017), 2017, Accessed: 00, 2021. [Online]. Available: