Bifonksiyonel Skuaramit Organokatalizörler ile Malononitrilin Çalkona Enantiyoseçici Michael Katılması

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2015-03-22

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Sargın, Nurdan
Tanyeli, Cihangir

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https://hdl.handle.net/11511/74205

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Bifonksiyonel OrganokatalizörlerinDekarboksilatif Aldol Tepkimelerinde İncelenmesi Bayer, Ezgi; Tanyeli, Cihangir (null; 2017-09-10)
Enantioselective Michael addition of diethyl malonate to nitroolefins with bifunctional 2-aminodmap/urea organocatalyst Bakırcı Çetinkaya, İrem; Tanyeli, Cihangir; Department of Chemistry (2016) The enantioselective organocatalytic Michael addition reaction has gained increased attention as an asymmetric synthesis strategy for C-C bond formation. In this regard, (1R,2R)-trans-1,2-cyclohexanediamine derived C1 symmetrical 2-aminoDMAP has been synthesized in our group. The remaining primary amine was modified with 1-isothiocyanato-(3,5)-bis(trifluoromethyl) benzene 3,5-Bis (trifluoromethyl) phenyl isothiocyanate and 3,5-bis(trifluoromethyl) phenyl isocyanate to afford bifunctional 2-aminoDMAP/thioure...
Enantioselective Michael addition of malononitrile to chalcone with bifunctional squaramide organocatalysts Sargın, Nurdan; Tanyeli, Cihangir; Department of Chemistry (2015) 4H-pyran derivatives show diverse biological activity such as antimicrobial, antibacterial, antiviral and antifungal. 4H-pyran derivatives can be synthesized easily from 2-(3-oxo-1,3-diphenylpropyl)malononitrile which is the Michael addition product of malononitrile to trans-chalcone. Synthesizing chiral biologically active compounds with metal free approach (organocatalysis) is a significant topic. In this thesis, chiral 2-(3-oxo-1,3-diphenylpropyl)malononitrile was synthesized with quinine or 2-aminoDMAP ...
Synthesis of bifunctional 2-aminodmap/prolinamide organocatalysts and their use in asymmetric michael reaction to afford warfarin Akkoca, Hasan Ufuk; Tanyeli, Cihangir; Department of Chemistry (2012) In the first part of this thesis, the construction of the novel bifunctional proline-(1R,2R)-2-aminoDMAP organocatalyst backbone is described. Target compound has both Lewis base and Brønsted acid catalaphoric sites. The Lewis base site is synthesized via selective mono-N-pyridilization of trans-(1R,2R)-cyclohexane-1,2-diamine by Cu catalysis and Brønsted acid site is subsequently introduced by anchoring L-proline unit. In the second part, catalytic activities of organocatalysts are tested in asymmetric Mic...
Enantioselective aza-Henry reaction of t-boc protected imines and nitroalkanes with bifunctional squaramide organocatalysts Susam, Dilşad; Tanyeli, Cihangir; Department of Chemistry (2015) The first part of this thesis comprises the application of a Cinchona alkaloid derived, bifunctional squaramide organocatalyst in the aza-Henry reaction of t-Boc protected imines and nitroalkanes. The target chiral β-nitroamines are chosen because; they are quite feasible for the corresponding α-amino acids and 1,2-diamines, which are basic structural motif in many natural products and key materials of the many pharmaceuticals. In this part, 12 different chiral β-nitroamine derivatives were synthesized with...

Citation Formats

N. Sargın and C. Tanyeli, “Bifonksiyonel Skuaramit Organokatalizörler ile Malononitrilin Çalkona Enantiyoseçici Michael Katılması,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/74205.