Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Bifonksiyonel OrganokatalizörlerinDekarboksilatif Aldol Tepkimelerinde İncelenmesi
Date
2017-09-10
Author
Bayer, Ezgi
Tanyeli, Cihangir
Metadata
Show full item record
Item Usage Stats
158
views
0
downloads
Cite This
URI
https://hdl.handle.net/11511/81459
Collections
Unverified, Conference / Seminar
Suggestions
OpenMETU
Core
Bifonksiyonel Skuaramit Organokatalizörler ile Malononitrilin Çalkona Enantiyoseçici Michael Katılması
Sargın, Nurdan; Tanyeli, Cihangir (2015-03-22)
Asymmetric synthesis of tetrahydrothiophenes in the presence of bifunctional organocatalysts
Tümer, Mustafa Faik; Tanyeli, Cihangir; Department of Chemistry (2021-1-22)
In general, nitroolefins are convenient structures as Michael acceptors. To make it clear for this work, attack of a sulfur-containing nucleophile to a nitroolefin forms a C-S bond and opening the double bond would create a nucleophilic center on the nitroolefin which leads to the formation of a new C-C bond. In this study, asymmetric organocatalytic sulfa-Michael addition of 1,4-dithiane-2,5-diol to trans-β-nitrostyrene derivatives was carried out which yielded polyfunctional tetrahydrothiophenes that have...
Enantioselective aza-Henry reaction of t-boc protected imines and nitroalkanes with bifunctional squaramide organocatalysts
Susam, Dilşad; Tanyeli, Cihangir; Department of Chemistry (2015)
The first part of this thesis comprises the application of a Cinchona alkaloid derived, bifunctional squaramide organocatalyst in the aza-Henry reaction of t-Boc protected imines and nitroalkanes. The target chiral β-nitroamines are chosen because; they are quite feasible for the corresponding α-amino acids and 1,2-diamines, which are basic structural motif in many natural products and key materials of the many pharmaceuticals. In this part, 12 different chiral β-nitroamine derivatives were synthesized with...
Enantioselective Michael addition of malononitrile to chalcone with bifunctional squaramide organocatalysts
Sargın, Nurdan; Tanyeli, Cihangir; Department of Chemistry (2015)
4H-pyran derivatives show diverse biological activity such as antimicrobial, antibacterial, antiviral and antifungal. 4H-pyran derivatives can be synthesized easily from 2-(3-oxo-1,3-diphenylpropyl)malononitrile which is the Michael addition product of malononitrile to trans-chalcone. Synthesizing chiral biologically active compounds with metal free approach (organocatalysis) is a significant topic. In this thesis, chiral 2-(3-oxo-1,3-diphenylpropyl)malononitrile was synthesized with quinine or 2-aminoDMAP ...
Enantioselective formal synthesis of pregabalin with bifunctional acid/base organocatalysts
Kapucu, Merve; Tanyeli, Cihangir; Department of Chemistry (2013)
Pregabalin, which is marketed under the brand name of Lyrica by Pfizer, is an important chiral drug in the treatment of epilepsy and neuropathic pain. Since only S-Pregabalin is active for the treatment, asymmetric synthesis was accomplished in 6 steps and the chiral induction was done by transition metal catalysis in industrial production. In this thesis, we applied an alternative synthetic route taken place in 3 steps. The key step comprised the chiral induction done by organocatalysis and the formal asym...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
E. Bayer and C. Tanyeli, “Bifonksiyonel OrganokatalizörlerinDekarboksilatif Aldol Tepkimelerinde İncelenmesi,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/81459.