Reduced Adhesion of Macrophages On Nanotubular PDMS Molds for Catheter Applications

Date

2013-12-31

Author

Lıu, Lutıng
Ercan, Batur
Sun, Lınlın
Webster, Thomas

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Polydimethylsiloxane (PDMS) has been used for short- and long-term catheters. However, PDMS shunt tubing has been scrutinized recently because of their extremely high failure rates. While there are many reasons why PDMS shunt systems fail, one is tissue occlusion of the ventricular catheter, most often caused by macrophages. It is hypothesized that nanotextured and nanotubular surfaces can be carefully manipulated to inhibit immune cell (specifically, macrophages) and improve the fibroblast adhesion due to their unique surface energy properties which have the ability to control initial protein absorption and subsequent cell behavior. The objective of this in vitro study was to create polydimethylsiloxane (PDMS) molds of titanium (Ti) anodized to possess nanotubes and test inflammatory cell and fibroblast responses on such substrates.

URI

https://www.aiche.org/conferences/aiche-annual-meeting/2013/proceeding/paper/67h-reduced-adhesion-macrophages-on-nanotubular-pdms-molds-catheter-applications-1
https://hdl.handle.net/11511/78560

Conference Name

2013 AICHE Annual Meeting (3 - 8 Kasım 2013)

Collections

Department of Metallurgical and Materials Engineering, Conference / Seminar

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Citation Formats

L. Lıu, B. Ercan, L. Sun, and T. Webster, “Reduced Adhesion of Macrophages On Nanotubular PDMS Molds for Catheter Applications,” presented at the 2013 AICHE Annual Meeting (3 - 8 Kasım 2013), San Francisco, USA, 2013, Accessed: 00, 2021. [Online]. Available: https://www.aiche.org/conferences/aiche-annual-meeting/2013/proceeding/paper/67h-reduced-adhesion-macrophages-on-nanotubular-pdms-molds-catheter-applications-1.