Immunoadjuvant action of liposomes containing interleukin-2 as a co-adjuvant

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1995-01-01

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Gürsel, Mayda

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0029089771&origin=inward
https://hdl.handle.net/11511/78595

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Immunoadjuvant action of plasmid DNA in liposomes Gürsel, Mayda; Ozkan, M; Özcengiz, Gülay (1999-03-17) Bacterial DNA and oligodeoxynucleotides containing immunostimulatory sequences with a CpG motif stimulated a Th1 type response in vivo. The adjuvant action of a non-coding plasmid DNA derived from pRc/CMV HBS (encoding the S region of hepatitis B surface antigen, HBsAg) in mice was investigated. The role of methylation on the adjuvanticity of the plasmid as well as the effect of vaccine formulation employed on the outcome of antigen-specific humoral and cellular responses were also studied. The results demo...
Immunotherapeutic applications of CpG ODN Gürsel, Mayda (2006-06-01) Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines. CpG ODN directly stimulate lymphocytes, natural killer cells and professional antigen-presenting cells (such as macrophages and dendritic cells). Owing to the strength and nature of this stimulation, CpG ODN are being harnessed f...
Immunohistochemical localization of glutathione S-transferases in normal and carcinoma human breast tissue Oğuztüzün, Serpil; İşcan, Mesude; Dizbay Sak, Serpil; Department of Biology (2000)
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides. Ishii, KJ; Gursel, I; Gürsel, Mayda; Klinman, DM (2004-04-01) Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9 on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins. Synthetic oligodeoxynucleotides (ODNs) containing CpG motifs mimic the activity of bacterial DNA. Recently, several structurally distinct types of CpG ODN were identified that differentially activate human immune cells. These ODNs may be useful as vaccine adjuvants, anti-allergens and in the treatment of infectious diseases and ...
Immunotherapeutic applications of CpG-containing oligodeoxynucleotides Klinman, DM; Ishii, KJ; Gürsel, Mayda; Gursel, I; Takeshita, S; Takeshita, F (2000-06-01) Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines. CpG ODN directly stimulate lymphocytes, natural killer cells and professional antigen-presenting cells (such as macrophages and dendritic cells). Owing to the strength and nature of this stimulation, CpG ODN are being harnessed f...

Citation Formats

M. Gürsel, “Immunoadjuvant action of liposomes containing interleukin-2 as a co-adjuvant,” 1995, p. 572, Accessed: 00, 2021. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0029089771&origin=inward.