Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides.

Date

2004-04-01

Author

Ishii, KJ
Gursel, I
Gürsel, Mayda
Klinman, DM

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

147
views

0
downloads

Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9 on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins. Synthetic oligodeoxynucleotides (ODNs) containing CpG motifs mimic the activity of bacterial DNA. Recently, several structurally distinct types of CpG ODN were identified that differentially activate human immune cells. These ODNs may be useful as vaccine adjuvants, anti-allergens and in the treatment of infectious diseases and cancer. Yet CpG-driven immune activation can have deleterious consequences, such as increasing the host's susceptibility to autoimmune disease. The immunomodulatory activity of CpG DNA can be blocked by DNA containing G-rich 'suppressive' motifs. The therapeutic potential of these immunostimulatory and immunosuppressive ODNs are discussed in this review.

Subject Keywords

CpG DNA, Immunotherapy, Innate immunity, suppressive ODNs; toll-like receptor 9,

URI

https://hdl.handle.net/11511/54476

Journal

Current opinion in molecular therapeutics

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Immunotherapeutic applications of CpG-containing oligodeoxynucleotides Klinman, DM; Ishii, KJ; Gürsel, Mayda; Gursel, I; Takeshita, S; Takeshita, F (2000-06-01) Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines. CpG ODN directly stimulate lymphocytes, natural killer cells and professional antigen-presenting cells (such as macrophages and dendritic cells). Owing to the strength and nature of this stimulation, CpG ODN are being harnessed f...
Immunoadjuvant action of plasmid DNA in liposomes Gürsel, Mayda; Ozkan, M; Özcengiz, Gülay (1999-03-17) Bacterial DNA and oligodeoxynucleotides containing immunostimulatory sequences with a CpG motif stimulated a Th1 type response in vivo. The adjuvant action of a non-coding plasmid DNA derived from pRc/CMV HBS (encoding the S region of hepatitis B surface antigen, HBsAg) in mice was investigated. The role of methylation on the adjuvanticity of the plasmid as well as the effect of vaccine formulation employed on the outcome of antigen-specific humoral and cellular responses were also studied. The results demo...
Immunotherapeutic applications of CpG ODN Gürsel, Mayda (2006-06-01) Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines. CpG ODN directly stimulate lymphocytes, natural killer cells and professional antigen-presenting cells (such as macrophages and dendritic cells). Owing to the strength and nature of this stimulation, CpG ODN are being harnessed f...
Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Takeshita, F; Gursel, I; Ishii, KJ; Suzuki, K; Gürsel, Mayda; Klinman, DM (2004-02-01) Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG ...
Molecular mechanism of estrogen-estrogen receptor signaling. Yaşar, P; Ayaz, G; User, Sd; Güpür, G; Muyan, Mesut (2016-12-05) 17 beta-Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)alpha and ER beta that are encoded by distinct genes. Localized at the pen-membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ERs share similar, as well as distinct, regulatory potentials. Different intracellular localizations of the ERs result ...

Citation Formats

K. Ishii, I. Gursel, M. Gürsel, and D. Klinman, “Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides.,” Current opinion in molecular therapeutics, pp. 166–74, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54476.