15 Yılın Birikimi: docomomo-tr.org

Date

2018-03-20

Author

Altan, Tomris Elvan
Salman, Sakine Yıldız

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https://hdl.handle.net/11511/78915

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The Effect of 15-lipoxygenase-1 (15-LOX-1) on angiogenesis in colorectal and prostate cancer Çolakoğlu, Melis; Banerjee, Sreeparna; Department of Biology (2017) 15-lipoxygenase-1 (15-LOX-1) is one of the lipoxygenases (LOX) that are important for the generation of inflammatory bioactive lipids, which then result in the initiation and resolution of inflammation. The enzyme mainly metabolizes the omega-6 fatty acid, linoleic acid, to 13-(S)-HODE. In colorectal carcinoma, the tumor suppressive role of 15-LOX-1 is highlighted with decreased proliferation, induction of apoptosis, reduced motility and invasion. Oppositely, the expression of 15-LOX-1 was reported to have ...
Functional characterization of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line ht-29 Tunçay, Seda; Banerjee, Sreeparna; Department of Biology (2009) Colorectal carcinoma (CRC) is often lethal when invasion and/or metastasis occur. 15-lipoxygenase-1 (15-LO-1), an enzyme of the inflammatory eicosanoid pathway, oxidatively metabolizes linoleic acid and its expression is repressed in CRC. In the present study, the hypothesis that the lack of 15-LO-1 expression in CRC cells may contribute to the tumorigenesis was investigated. Therefore 15-LO-1 was introduced to colon cancer cell line HT-29 that does not have detectable levels of the 15-LO-1. The HT-29 cells...
Effects of 15-lipoxygenase-1 on the angiogenic properties of colorectal cancer cell line SW480 Yener, Caner; Banerjee, Sreeparna; Erel Göktepe, İrem; Department of Biochemistry (2016) Colorectal cancer is a disease resulting from the malignant transformation of colon epithelia. As of 2013, it the third leading cause of death among cancer related deaths, in Turkey. Lipoxygenases (LOXs) are a family of fatty acid dioxygenases that convert polyunsaturated fatty acids (PUFAs) to their oxidized form, which are subsequently transformed to bioactive lipid mediators acting in various cell functions. Specifically, 15-Lipoxygenase-1 (15-LOX-1) is a member of the LOX family, oxygenating linoleic ac...

Citation Formats

T. E. Altan and S. Y. Salman, “15 Yılın Birikimi: docomomo-tr.org,” 2018, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/78915.