Advanced mathematical and statistical tools in the dynamic modelling and simulation of gene-environment networks

2014-01-01
Purutçuoğlu Gazi, Vilda
Weber, Gerhard Wilhelm
In this study, some methodologies and a review of the recently obtained new results are presented for the problem of modeling, anticipation and forecasting of genetic regulatory systems, as complex systems. In this respect, such kind of complex systems are modeled in the dynamical sense into the two different ways, namely, by a system of ordinary differential equations (ODEs) and Gaussian graphical methods (GGM). An artificial time-course microarray dataset of a gene-network is modeled as an example by using both ODE method and GGM. In this analysis, since the actual interactions of the nodes, i.e., genes, are assumed to be unknown, the discrete time measurements are initially used for the inference of the system’s interactions, i.e., the edges between nodes, by the underlying two methods. Then, the results of inference from ordinary differential equation based model are applied to a class of previously developed new numerical schemes for the generation of further states of the system. In this simulation, we present the recent results of a set of explicit Runge-Kutta methods that are implemented.
Citation Formats
V. Purutçuoğlu Gazi and G. W. Weber, Advanced mathematical and statistical tools in the dynamic modelling and simulation of gene-environment networks. 2014, p. 257.