In vivo investigation of metabolic changes occurring in the rat brain hippocampus after fluoxetine administration using two complementary techniques: solid phase microextraction and microdialysis

Boyacı, Ezel
Lendor, Sofia
Reyes Garces, Nathaly
Gomez Rios, German Augusto
Bojko, Barbara
Hamani, Clement
Pawliszyn, Janusz


Petekkaya, Ali Tolga; Tönük, Ergin (2011-03-01)
Mechanical interaction of human body with surrounding is mostly via soft tissues because human body is nearly entirely covered with them. Finite element method, extensively used in various fields of engineering, could not reach to a similar success in simulating soft tissues (especially for modeling the interaction with exoskeletal prosteses and orthoses) mainly because soft tissue mechanical behavior is not known in detail in addition to relatively complex mechanical response of soft tissues.
In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis
Gursel, I; Korkusuz, F; Turesin, F; Alaeddinoglu, NG; Hasırcı, Vasıf Nejat (2001-01-01)
In this study the construction and in vivo testing of antibiotic-loaded polyhydroxyalkanoate rods were planned for use in the treatment of implant-related osteomyelitis. The rods were constructed of poly(3-hydroxybutyrare-co-3-hydroxyvalerate) and poly(3hydroxybutyrate-co-4-hydroxybutyrate), carrying 50% (w/w) Sulperazone(R) or Duocid(R). They were implanted in rabbit tibia in which implant-related osteomyelitis (IRO) had been induced with Staphylococcus aureus. The effectiveness of the antibiotics in the t...
In vivo examination of the effects of hydroxycinnamic acid on xenobiotic metabolizing and antioxidant enzymes
SEMİZ, ASLI; Celik-Turgut, Gurbet; KARAKURT, SERDAR; AKÇA, HAKAN; ARSLAN, ŞEVKİ; Adalı, Orhan; ŞEN, ALAATTİN (National Library of Serbia, 2017-01-01)
In the last decade, hydroxycinnamic acids (HCA) have gained increasing attention from researchers due to their antioxidant potential. The aim of this study was to examine in detail the impact of dietary HCA on particular types of P450 and also selected phase II and antioxidant enzymes in Wistar rat. HCA (10 mu M/kg/day, i.p.) was administered for ten continuous days. Examination of the activities and mRNA and protein levels revealed that CYP2B, 2C6 and 3A enzyme activities were not altered significantly, wi...
In vivo brain sampling using a microextraction probe reveals metabolic changes in rodents after deep brain stimulation
Reyes-Garcés, Nathaly; Diwan, Mustansir; Boyacı, Ezel; Gómez-Ríos, German A.; Bojko, Barbara; Nobrega, José N.; Bambico, Francis R.; Hamani, Clement; Pawliszyn, Janusz (American Chemical Society (ACS), 2019-08-06)
Brain metabolomics is an emerging field that complements the more traditional approaches of neuroscience. However, typical brain metabolomics workflows require that animals be sacrificed and tend to involve tedious sample preparation steps. Microdialysis, the standard technique to study brain metabolites in vivo, is encumbered by significant limitations -in the analysis of hydrophobic metabolites, which are prone to adsorption losses on microdialysis equipment. An alternative sampling method suitable for in...
In Vivo Performance of Poly(epsilon-caprolactone) Constructs Loaded with Gentamicin Releasing Composite Microspheres for Use in Bone Regeneration
Sezer, Umran Aydemir; BİLLUR, DENİZ; HURİ, GAZİ; Huri, Pinar Yilgor; AKSOY, EDA AYŞE; Terzioglu, Hakan; Konukseven, Erhan İlhan; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2014-10-01)
For materials used in the production of dental and orthopedic implants or scaffolds for bone tissue regeneration, the properties such as capacity to enhance cell attachment and proliferation, and antimicrobial activity to prevent biofilm formation are very important to improve the clinical utility of the material. In this study, poly(epsilon-caprolactone) (PCL) sponges with antimicrobial activity were prepared by incorporating gentamicin loaded beta-tricalcium phosphate (beta-TCP)-Gelatin microspheres, and ...
Citation Formats
E. Boyacı et al., “In vivo investigation of metabolic changes occurring in the rat brain hippocampus after fluoxetine administration using two complementary techniques: solid phase microextraction and microdialysis,” 2019, Accessed: 00, 2021. [Online]. Available: