Molecular Profile of the Apoptosis Related Genes in Breast Cancer Cells after Treatment with CpG Oligodeoxynucleotides Delivered by PAMAM Coated Magnetic Nanoparticles

Pourianazar, Negar
Gündüz, Ufuk


Molecular analysis of beta lactamases in clinical acinetobacter baumannii ısolates from intensive care units
Güçlü Üsküdar, Aylin; Gözen, Ayşe Gül; Department of Biology (2011)
Carbapenem resistance in Acinetobacter baumannii is a growing public health concern and represents a serious problem for treatment of the infection. Several carbapenem-hydrolysing β-lactamases have been identified from A. baumannii so far. In this study carbapenem resistance in A.baumannii strains recovered from intensive care units of Gulhane Military Medical Academy, Turkey, were investigated via multiplex PCR and with parallel phenotypic tests. From June 2006 to January 2010, 138 clinical A. baumannii is...
Molecular investigation of therapeutical effects of Ɣ-tocotrienol conjugation therapy with doxorubicin on hepatocellular carcinoma cell line HePG2
Özyurt, İpek; Son, Çağdaş Devrim; Department of Biology (2017)
Hepatocellular carcinoma (HCC) is the fifth leading tumor of the liver tissue in terms of frequency of occurrence and third in terms of mortality. Even though, the most widely used chemotherapeutic agent doxorubicin in treatment of HCC had a great impact for development of therapeutic strategies preventing the progression of tumor formation and elucidating the physiological characteristics of tumor tissue. Moreover, use of doxorubicin minimizes the side effects of the drug in the individual and prevents the...
Molecular characterization of the effects of valdecoxib on colon cancer cell lines (ht29 & sw620) using ATR-FTIR spectroscopy
İnan Genç, Aysun; Severcan, Feride; Banerjee, Sreeparna; Department of Biochemistry (2014)
Colorectal cancer is the third most common malignancy and the fourth most frequent cause of cancer deaths worldwide, with 945,000 estimated new cases and 492,000 deaths per year in industrialized countries. Chronic inflammation of the bowel is associated with increased levels of pro-inflammatory cytokines and the increased signaling, which plays important roles in the development of carcinoma. During chronic inflammation COX-2 levels are dramatically increased which is the main enzyme in the arachidonic aci...
Molecular footprint of Medawar's mutation accumulation process in mammalian aging
Turan, Zeliha Gozde; Parvizi, Poorya; Donertas, Handan Melike; Tung, Jenny; Khaitovich, Philipp; Somel, Mehmet (2019-08-01)
Medawar's mutation accumulation hypothesis explains aging by the declining force of natural selection with age: Slightly deleterious germline mutations expressed in old age can drift to fixation and thereby lead to aging-related phenotypes. Although widely cited, empirical evidence for this hypothesis has remained limited. Here, we test one of its predictions that genes relatively highly expressed in old adults should be under weaker purifying selection than genes relatively highly expressed in young adults...
Molecular investigation of ptz-induced epileptic activities in rat brain cell membranes and the effects of vigabatrin
Görgülü Türker, Sevgi; Severcan, Feride; Department of Biology (2009)
The epilepsies are a heterogenous group of symptom complexes, whose common features is the recurrence of seizures. There is no certain therapy for epilepsy. In order to promote new advances for the prevention of epilepsy the molecular mechanism of epileptic activities should be clarified. In the present study the goal is to obtain information for molecular mechanism of epilepsy. To achieve this, molecular alterations from pentylenetetrazol (PTZ)-induced epileptic activities on rat brain tissue and cell memb...
Citation Formats
N. Pourianazar and U. Gündüz, “Molecular Profile of the Apoptosis Related Genes in Breast Cancer Cells after Treatment with CpG Oligodeoxynucleotides Delivered by PAMAM Coated Magnetic Nanoparticles,” presented at the The 7th EMBO Meeting 2016 (3 - 13 Eylül 2016), Mannheim, Almanya, 2016, Accessed: 00, 2021. [Online]. Available: