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Proteome-wide analysis of pleiotropic effects of targeted homoserine dehydrogenase (hom) gene disruption in Streptomyces clavuligerus
Date
2018-10-01
Author
Özcengiz, Gülay
Kurt Kızıldoğan, Aslıhan
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https://hdl.handle.net/11511/86881
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Proteome-wide analysis of pleiotropic effects of targeted homoserine dehydrogenase (hom) gene disruption in Streptomyces clavuligerus
Zcengiz, G.; Nsaldi, E.; Aktas, C.; Ertekin, Ozan; KURT KIZILDOĞAN, ASLIHAN; Zcan, S. (2018-10-10)
Proteome-wide analysis of the functional roles of bacilysin biosynthesis in Bacillus subtilis
Özcengiz, Gülay (2014-07-13)
Proteome-wide analysis of the functional roles of bacilysin biosynthesis in Bacillus subtilis
Özcengiz, Gülay; Demir, Mustafa; Karatas, Ayten Yazgan (2014-07-01)
The members of the genus Bacillus produce a wide variety of secondary metabolites with antimetabolic and pharmacological activities. Most of these metabolites are small peptides that have unusual components and chemical bonds and synthesized nonribosomally by multifunctional enzyme complexes called peptide synthetases. Bacilysin, being produced and excreted by certain strains of Bacillus subtilis, is one of the simplest peptide antibiotics known. It is a dipeptide with an N-terminal Lalanine and an unusual ...
Proteome-wide analysis of the functional roles of Bacilysin biosynthesis in Bacillus subtilis
Taşkın Aras, Aslı; Özcengiz, Gülay; Department of Biology (2010)
The members of the genus Bacillus produce a wide variety of secondary metabolites with antimetabolic and pharmacological activities. Most of these metabolites are small peptides that have unusual components and chemical bonds and synthesized nonribosomally by multifunctional enzyme complexes called peptide synthetases. Bacilysin, being produced and excreted by certain strains of Bacillus subtilis, is one of the simplest peptide antibiotics known. It is a dipeptide with an N-terminal L-alanine and an unusual...
Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus
Unsaldi, Eser; Kurt-Kizildogan, Aslihan; Voigt, Birgit; Becher, Doerte; Özcengiz, Gülay (2017-03-01)
The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains. An industrial clavulanic acid (CA)-overproducer Streptomyces clavuligerus DEPA was assessed to understand proteome-wide changes that have occurred in a local industrial CA overproducer developed through succesive mutagenesis programs. The proteins that could ...
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G. Özcengiz and A. Kurt Kızıldoğan, “Proteome-wide analysis of pleiotropic effects of targeted homoserine dehydrogenase (hom) gene disruption in Streptomyces clavuligerus,” 2018, vol. 44, p. 109, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/86881.