Investigation of the effect of sodium butyrate induced differentiation on inflammatory pathways in colon cancer cells
Küçükdemir, Mümine; Banerjee, Sreeparna; Department of Biology (2012)
Sodium butyrate (NaBt) is a four-carbon short chain fatty acid, produced naturally in colon as the end product of the bacterial anaerobic metabolism on dietary fibers. It was previously shown that NaBt can induce differentiation and may inhibit proliferation. The objective of this study was to investigate the effect of NaBt-induced differentation on inflammatory pathways in HT29 colon cancer cells. For this purpose, first, cells were treated with varying concentrations of NaBt from 1-5 mM and amount require...
Investigation of the effects of nutrient restriction on endolysosomal signaling in colorectal cancer (CRC) cells.
Gulec, Aliye E.; Hüsnügil, Hepşen Hazal; Oral, Goksu; Sheraj, Ilir; Banerjee, Sreeparna (2021-07-01)
Investigation of the role of programmed cell death 10 (PDCD10) protein in multidrug resistance
Urfalı Mamatoğlu, Çağrı; Gündüz, Ufuk; Department of Biology (2018)
Drug resistance, a major obstacle in chemotherapy, is the sum of several cellular alterations including resistance to induction of apoptosis. Apoptosis is a well-regulated cell death mechanism which is controlled by several signaling pathways and a vast number of proteins. Alterations in the proteins involved in the apoptotic regulation have been associated with drug resistance in cancer. Programmed Cell Death 10 (PDCD10) protein is a novel apoptotic regulator that is recently linked to the modulation of ce...
Investigation of the lipid metabolic changes induced by novel alpha tocopherol analog (TC6OH) in luminal a type breast cancer cells
Gök, Seher; Severcan, Feride; Department of Biology (2017)
Although the traditional chemotherapeutic agents able to suppress breast tumor progression, they are mostly unspecific in their mechanism of action and have toxic effects to normal tissues. Instead, it has been reported that tumor cells are more sensitive to some forms of Vitamin E (VE) and its synthetic derivatives than healthy cells. Studies of drug-cell interactions and understanding the mechanism underlying cytotoxic activity and biological effects at molecular level in cancer model cells are essential ...
Investigation of the effect of sodium butyrate on the regulation of cyclooxygenase-2 in colon cancer cell lines Caco-2 and HT-29
Ülgen, Doğukan Hazar; Banerjee, Sreeparna; Department of Biology (2015)
Sodium butyrate (NaBt) is a four-carbon short-chain fatty acid histone deacetylase inhibitor (HDACi) that is available in the colon through the commensal microbiota-mediated fermentation of dietary fibers. It is the main source of energy for colonocytes, and is regarded to have tumor suppressive effects, most prominently in colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is a gene important in the inflammatory response due to its ability to convert arachidonic acid to prostaglandins. Overexpression and ov...
Citation Formats
H. H. Hüsnügil, G. Oral, A. E. Erson Bensan, and S. Banerjee, “INVESTIGATION OF THE EFFECTS OF NUTRIENT RESTRICTION ON LYSOSOMAL TRAFFICKING IN COLORECTAL CANCER CELLS,” presented at the AACR ANNUAL MEETING 202, Oregon, Amerika Birleşik Devletleri, 2021, Accessed: 00, 2021. [Online]. Available: