Investigation of the effects of nutrient restriction on endolysosomal signaling in colorectal cancer (CRC) cells.

Date

2021-07-01

Author

Gulec, Aliye E.
Hüsnügil, Hepşen Hazal
Oral, Goksu
Sheraj, Ilir
Banerjee, Sreeparna

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URI

https://hdl.handle.net/11511/92028

Journal

CANCER RESEARCH

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Department of Biology, Article

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INVESTIGATION OF THE EFFECTS OF NUTRIENT RESTRICTION ON LYSOSOMAL TRAFFICKING IN COLORECTAL CANCER CELLS Hüsnügil, Hepşen Hazal; Oral, Göksu; Erson Bensan, Ayşe Elif; Banerjee, Sreeparna (2021-04-10)
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Investigation of the effect of sodium butyrate induced differentiation on inflammatory pathways in colon cancer cells Küçükdemir, Mümine; Banerjee, Sreeparna; Department of Biology (2012) Sodium butyrate (NaBt) is a four-carbon short chain fatty acid, produced naturally in colon as the end product of the bacterial anaerobic metabolism on dietary fibers. It was previously shown that NaBt can induce differentiation and may inhibit proliferation. The objective of this study was to investigate the effect of NaBt-induced differentation on inflammatory pathways in HT29 colon cancer cells. For this purpose, first, cells were treated with varying concentrations of NaBt from 1-5 mM and amount require...
Investigation of telomerase activity and gene expression in colorectal cancer İzgi, Ahu; Gündüz, Ufuk; Department of Biology (2012) Human telomerase is a reverse transcriptase which synthesizes telomeric repeat sequences at the ends of chromosomes. The telomerase enzyme has two essential subunits to be functional which are called telomerase reverse transcriptase (hTERT) and human telomerase RNA (hTR). Telomerase uses its RNA subunit as a template for the addition of hexameric repeats at the ends of chromosomes. The activity of telomerase has been detected in immortal cells but not in most normal somatic cells. Therefore, its activity co...
Investigation of the effect of sodium butyrate on the regulation of cyclooxygenase-2 in colon cancer cell lines Caco-2 and HT-29 Ülgen, Doğukan Hazar; Banerjee, Sreeparna; Department of Biology (2015) Sodium butyrate (NaBt) is a four-carbon short-chain fatty acid histone deacetylase inhibitor (HDACi) that is available in the colon through the commensal microbiota-mediated fermentation of dietary fibers. It is the main source of energy for colonocytes, and is regarded to have tumor suppressive effects, most prominently in colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is a gene important in the inflammatory response due to its ability to convert arachidonic acid to prostaglandins. Overexpression and ov...

Citation Formats

A. E. Gulec, H. H. Hüsnügil, G. Oral, I. Sheraj, and S. Banerjee, “Investigation of the effects of nutrient restriction on endolysosomal signaling in colorectal cancer (CRC) cells.,” CANCER RESEARCH, vol. 81, no. 13, pp. 0–0, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/92028.