Investigation of a mechanistic link between 15-Lipoxygenase-1 (15-LOX-1) and Metastasis Associated Protein 1 (MTA1) in human colorectal carcinoma cell lines
ÇAĞATAY, SİBEL; Banerjee, Sreeparna (2013-09-01)
Background: Metastasis Associated Protein 1 (MTA1) is a member of the nuclear remodeling and histone deacetylase (NuRD) complex that is known to repress the expression of several tumor suppressor genes. 15-lipoxygenase-1 (15-LOX-1), a member of the inflammatory eicosanoid pathway, has been shown by us and others to have an anti-tumorigenic role in colon cancer. ALOX15 was recently shown to be repressed by the NuRD complex. Previously we have reported that ectopic expression of 15-LOX-1 in colon cancer cells...
Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway
Canli, Secil Demirkol; Seza, Esin Gulce; Sheraj, Ilir; Gomceli, Ismail; Turhan, Nesrin; Carberry, Steven; Prehn, Jochen H. M.; GÜRE, ALİ OSMAY; Banerjee, Sreeparna (Oxford University Press (OUP), 2020-09-01)
AKR1B1 and AKR1B10, members of the aldo-keto reductase family of enzymes that participate in the polyol pathway of aldehyde metabolism, are aberrantly expressed in colon cancer. We previously showed that high expression of AKR1B1 (AKR1B1(HIGH)) was associated with enhanced motility, inflammation and poor clinical outcome in colon cancer patients. Using publicly available datasets and ex vivo gene expression analysis (n = 51, Ankara cohort), we have validated our previous in silico finding that AKR1B1(HIGH) ...
Analysis of motifs in microRNA-transcription factor gene regulatory networks
Sürün, Bilge; Acar, Aybar Can; Purutçuoğlu Gazi, Vilda; Department of Bioinformatics (2014)
MicroRNAs are small non-coding RNA molecules which contain 21-25 nucleotides, and function in post transcriptional regulation by inhibiting the translation of mRNA targets. miRNAs typically affect gene regulation by forming composite feed forward circuits (cFFCs) which also comprise a transcription factor (TF) and a target gene. By analyzing these cFFCs, the contribution of miRNAs in altering TF networks can be revealed. These contributions could either be the de-escalation of the target gene repertoire or ...
Analysis of the effects of vancomycin containing bioceramic/polymer composites on biofilm prevention, biocompatibility and osteogenic modification of mesenchymal stem cells
Kankılıç, Berna; Bayramlı, Erdal; Korkusuz, Feza; Department of Biotechnology (2015)
Osteomyelitis is a difficult to treat bone infection. In clinic, osteomyelitis is treated with surgical debridement followed by the antibiotic therapy. But, due to the low blood circulation in the infection area and the production of an exopolysaccharide, biofilm, by the pathogen violence the treatment. Therefore local drug delivery systems are generated. These systems transmit the effective dose to the infection area without any toxic effects. In this study, vancomycin containing PDLLA/β-TCP and PLGA/β-TCP...
Analysis of the VIT1 Promoter Activity in Developing Arabidopsis thaliana Plants
Eroğlu, Seçkin (2021-10-01)
Iron (Fe) deficiency in plants is one of the widespread problems limiting agricultural production. Generating crops more tolerant to Fe deficiency by genetic engineering or breeding is of great interest but challenging due to the knowledge gaps in general plant Fe homeostasis. Although several genes involved in Fe homeostasis have been identified, characterization of their roles is mainly limited to specific organs at specific developmental stages of the plant, where their mutants show the most striking phe...
Citation Formats
H. H. Hüsnügil, I. Sheraj, A. E. Erson Bensan, and S. Banerjee, “ANALYSIS OF A POTENTIAL MICRORNA NETWORK THAT CO-REGULATES AUTOPHAGY AND EPITHELIAL TO MESENCHYMAL TRANSITION UNDER NUTRIENT RESTRICTION,” presented at the HIBIT 2020, İstanbul, Türkiye, 2020, Accessed: 00, 2021. [Online]. Available: